HIF1A,EPAS1 promote PTK6 gene expression

Stable Identifier
R-HSA-8848804
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
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HIF1A,EPAS1 promote PTK6 gene expression
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Binding of HIF1A (HIF1-alpha) and/or EPAS1 (HIF2A) to hypoxia response elements (HREs) in the promoter region of the PTK6 (BRK) gene stimulates PTK6 transcription at hypoxia (Regan Anderson et al. 2013). EPAS1 was recently reported to cooperate with the activated glucocorticoid receptor NR3C1 (GCR) and its cofactor PELP1 in the stimulation of PTK6 transcription (Regan Anderson et al. 2016).

Literature References
PubMed ID Title Journal Year
26825173 Breast Tumor Kinase (Brk/PTK6) is Induced by HIF, Glucocorticoid Receptor and PELP1 Mediated Stress Signaling in Triple-Negative Breast Cancer

Regan Anderson, TM, Lange, CA, Seagroves, TN, Ma, SH, Helle, TM, Krutilina, R, Knutson, TP, Cidlowski, JA, Raj, GV

Cancer Res. 2016
23928995 Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression

Wenger, RH, Regan Anderson, TM, Lange, CA, Schörg, A, Seagroves, TN, Lofgren, KA, Girard, BJ, Peacock, DL, Hoogewijs, D, Hubbard, GK, Daniel, AR

Cancer Res. 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
HIF1A,EPAS1:PTK6 Gene [nucleoplasm] (Homo sapiens)
Active Unit
HIF1A,EPAS1 [nucleoplasm]
Regulator
PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
Active Unit
PELP1 [nucleoplasm]
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
EPAS1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-11)
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