Reactome | HIF1A,EPAS1 promote PTK6 gene expression

HIF1A,EPAS1 promote PTK6 gene expression

Stable Identifier

R-HSA-8848804

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

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HIF1A,EPAS1 promote PTK6 gene expression

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Binding of HIF1A (HIF1-alpha) and/or EPAS1 (HIF2A) to hypoxia response elements (HREs) in the promoter region of the PTK6 (BRK) gene stimulates PTK6 transcription at hypoxia (Regan Anderson et al. 2013). EPAS1 was recently reported to cooperate with the activated glucocorticoid receptor NR3C1 (GCR) and its cofactor PELP1 in the stimulation of PTK6 transcription (Regan Anderson et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
26825173	Breast Tumor Kinase (Brk/PTK6) is Induced by HIF, Glucocorticoid Receptor and PELP1 Mediated Stress Signaling in Triple-Negative Breast Cancer Regan Anderson, TM, Ma, SH, Raj, GV, Cidlowski, JA, Helle, TM, Knutson, TP, Krutilina, R, Seagroves, TN, Lange, CA	Cancer Res.	2016
23928995	Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression Regan Anderson, TM, Peacock, DL, Daniel, AR, Hubbard, GK, Lofgren, KA, Girard, BJ, Schörg, A, Hoogewijs, D, Wenger, RH, Seagroves, TN, Lange, CA	Cancer Res.	2013