PTK6 phosphorylates DOK1

Stable Identifier
R-HSA-8848776
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PTK6 (BRK) phosphorylates tumor suppressor DOK1 on tyrosine residue Y362. PTK6-mediated phosphorylation of DOK1 targets DOK1, through an unknown mechanism, for ubiquitin-dependent proteasome degradation (Miah et al. 2014).

Literature References
PubMed ID Title Journal Year
24523872 BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration

Kalra, N, Dai, C, Lukong, KE, Goel, RK, Beaton-Brown, E, Bagu, ET, Bonham, K, Miah, S

PLoS ONE 2014
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6:DOK1 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!