PTK6 (BRK) phosphorylates tumor suppressor DOK1 on tyrosine residue Y362. PTK6-mediated phosphorylation of DOK1 targets DOK1, through an unknown mechanism, for ubiquitin-dependent proteasome degradation (Miah et al. 2014).
Kalra, N, Dai, C, Lukong, KE, Goel, RK, Beaton-Brown, E, Bagu, ET, Bonham, K, Miah, S
protein tyrosine kinase activity of p-Y342-PTK6:DOK1 [cytosol]
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