PTK6 phosphorylates DOK1

Stable Identifier
R-HSA-8848776
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PTK6 phosphorylates DOK1
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PTK6 (BRK) phosphorylates tumor suppressor DOK1 on tyrosine residue Y362. PTK6-mediated phosphorylation of DOK1 targets DOK1, through an unknown mechanism, for ubiquitin-dependent proteasome degradation (Miah et al. 2014).

Literature References
PubMed ID Title Journal Year
24523872 BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration

Miah, S, Goel, RK, Dai, C, Kalra, N, Beaton-Brown, E, Bagu, ET, Bonham, K, Lukong, KE

PLoS ONE 2014
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y342-PTK6:DOK1 [cytosol]
Physical Entity
p-Y342-PTK6:DOK1 [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
PTK6 phosphorylates DOK1 (Danio rerio)
PTK6 phosphorylates DOK1 (Drosophila melanogaster)
PTK6 phosphorylates DOK1 (Mus musculus)
PTK6 phosphorylates DOK1 (Rattus norvegicus)
PTK6 phosphorylates DOK1 (Sus scrofa)
PTK6 phosphorylates DOK1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-10)
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