PTK6 phosphorylates DOK1

Stable Identifier
R-HSA-8848776
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PTK6 phosphorylates DOK1
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PTK6 (BRK) phosphorylates tumor suppressor DOK1 on tyrosine residue Y362. PTK6-mediated phosphorylation of DOK1 targets DOK1, through an unknown mechanism, for ubiquitin-dependent proteasome degradation (Miah et al. 2014).

Literature References
PubMed ID Title Journal Year
24523872 BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration

Kalra, N, Dai, C, Lukong, KE, Goel, RK, Beaton-Brown, E, Bagu, ET, Bonham, K, Miah, S

PLoS ONE 2014
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6:DOK1 [cytosol]

Physical Entity
p-Y342-PTK6:DOK1 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
PTK6 phosphorylates DOK1 (Danio rerio)
PTK6 phosphorylates DOK1 (Mus musculus)
PTK6 phosphorylates DOK1 (Rattus norvegicus)
PTK6 phosphorylates DOK1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-10)
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