PTK6 phosphorylates DOK1

Stable Identifier
R-HSA-8848776
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PTK6 (BRK) phosphorylates tumor suppressor DOK1 on tyrosine residue Y362. PTK6-mediated phosphorylation of DOK1 targets DOK1, through an unknown mechanism, for ubiquitin-dependent proteasome degradation (Miah et al. 2014).

Literature References
PubMed ID Title Journal Year
24523872 BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration

Miah, S, Goel, RK, Dai, C, Kalra, N, Beaton-Brown, E, Bagu, ET, Bonham, K, Lukong, KE

PLoS ONE 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y342-PTK6:DOK1 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created
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