PTK6 phosphorylates BCAR1

Stable Identifier
R-HSA-8848726
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated PTK6 (BRK) phosphorylates BCAR1 (p130CAS) on tyrosine residues Y165 and Y664, and possibly other tyrosine residues. PTK6-mediated phosphorylation of BCAR1 contributes to formation of peripheral focal adhesion complexes involved in cell migration. Integrin receptors, growth factor receptors and ERK5 (MAPK7) contribute to PTK6-mediated formation of peripheral adhesion complexes (Zheng et al. 2012). PTK6-mediated phosphorylation of BCAR1 can also be triggered by UV-induced DNA damage and associated signaling (Chastkofsky et al. 2015).

Literature References
PubMed ID Title Journal Year
25938342 Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin

Chastkofsky, MI, Bie, W, Ball-Kell, SM, He, YY, Tyner, AL

J. Invest. Dermatol. 2015
22084245 Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate

Zheng, Y, Asara, JM, Tyner, AL

J. Biol. Chem. 2012
Participants
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Catalyst Activity
Title
protein tyrosine kinase activity of p-Y342-PTK6:BCAR1 [cytosol]
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Activity
Orthologous Events
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