Activated PTK6 (BRK) phosphorylates BCAR1 (p130CAS) on tyrosine residues Y165 and Y664, and possibly other tyrosine residues. PTK6-mediated phosphorylation of BCAR1 contributes to formation of peripheral focal adhesion complexes involved in cell migration. Integrin receptors, growth factor receptors and ERK5 (MAPK7) contribute to PTK6-mediated formation of peripheral adhesion complexes (Zheng et al. 2012). PTK6-mediated phosphorylation of BCAR1 can also be triggered by UV-induced DNA damage and associated signaling (Chastkofsky et al. 2015).
Zheng, Y, Tyner, AL, Asara, JM
Bie, W, Chastkofsky, MI, He, YY, Tyner, AL, Ball-Kell, SM
protein tyrosine kinase activity of p-Y342-PTK6:BCAR1 [cytosol]
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