Activated PTK6 (BRK) phosphorylates BCAR1 (p130CAS) on tyrosine residues Y165 and Y664, and possibly other tyrosine residues. PTK6-mediated phosphorylation of BCAR1 contributes to formation of peripheral focal adhesion complexes involved in cell migration. Integrin receptors, growth factor receptors and ERK5 (MAPK7) contribute to PTK6-mediated formation of peripheral adhesion complexes (Zheng et al. 2012). PTK6-mediated phosphorylation of BCAR1 can also be triggered by UV-induced DNA damage and associated signaling (Chastkofsky et al. 2015).
