PTK6 phosphorylates BCAR1

Stable Identifier
R-HSA-8848726
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PTK6 phosphorylates BCAR1
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Activated PTK6 (BRK) phosphorylates BCAR1 (p130CAS) on tyrosine residues Y165 and Y664, and possibly other tyrosine residues. PTK6-mediated phosphorylation of BCAR1 contributes to formation of peripheral focal adhesion complexes involved in cell migration. Integrin receptors, growth factor receptors and ERK5 (MAPK7) contribute to PTK6-mediated formation of peripheral adhesion complexes (Zheng et al. 2012). PTK6-mediated phosphorylation of BCAR1 can also be triggered by UV-induced DNA damage and associated signaling (Chastkofsky et al. 2015).
Literature References
PubMed ID Title Journal Year
22084245 Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate

Zheng, Y, Tyner, AL, Asara, JM

J. Biol. Chem. 2012
25938342 Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin

Bie, W, Chastkofsky, MI, He, YY, Tyner, AL, Ball-Kell, SM

J. Invest. Dermatol. 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6:BCAR1 [cytosol]

Physical Entity
p-Y342-PTK6:BCAR1 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
PTK6 phosphorylates BCAR1 (Bos taurus)
PTK6 phosphorylates BCAR1 (Mus musculus)
PTK6 phosphorylates BCAR1 (Rattus norvegicus)
PTK6 phosphorylates BCAR1 (Sus scrofa)
PTK6 phosphorylates BCAR1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-10)
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