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PTK6 binds BCAR1
Stable Identifier
R-HSA-8848713
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
PTK6 binds BCAR1 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated PTK6 (BRK) binds BCAR1 (p130CAS), and this interaction involves the SH2 domain of PTK6 (Zheng et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
22084245
Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate
Zheng, Y
,
Tyner, AL
,
Asara, JM
J. Biol. Chem.
2012
Participants
Input
BCAR1 [cytosol]
(Homo sapiens)
p-Y342-PTK6 [cytosol]
(Homo sapiens)
Output
p-Y342-PTK6:BCAR1 [cytosol]
(Homo sapiens)
Participates
as an event of
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
Orthologous Events
PTK6 binds BCAR1 (Bos taurus)
PTK6 binds BCAR1 (Mus musculus)
PTK6 binds BCAR1 (Rattus norvegicus)
PTK6 binds BCAR1 (Sus scrofa)
PTK6 binds BCAR1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2016-01-05)
Reviewed
Pires, IM (2016-02-07)
Created
Orlic-Milacic, M (2015-12-10)
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