Reactome | Activation of RAC1 by the PXN:CRK complex

Activation of RAC1 by the PXN:CRK complex

Stable Identifier

R-HSA-8848618

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Activation of RAC1 by the PXN:CRK complex

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PTK6 (BRK) mediated phosphorylation of PXN (paxillin), which may be triggered by EGF treatment, leads to formation of the RAC1 guanyl nucleotide exchange factor complex composed of PXN and the CRK (CrkII) complex, which includes DOCK180 and ELMO1 or ELMO2. Exchange of RAC1-bound GDP for GTP results in PTK6-induced RAC1 activation, which contributes to cell migration (Chen et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15572663	Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin Huang, YP, Tsai, YT, Shen, CH, Lin, FC, Chen, HY, Chen, RH	Mol. Cell. Biol.	2004