Reactome | Activation of RAC1 by the PXN:CRK complex

Activation of RAC1 by the PXN:CRK complex

Stable Identifier

R-HSA-8848618

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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Activation of RAC1 by the PXN:CRK complex

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PTK6 (BRK) mediated phosphorylation of PXN (paxillin), which may be triggered by EGF treatment, leads to formation of the RAC1 guanyl nucleotide exchange factor complex composed of PXN and the CRK (CrkII) complex, which includes DOCK180 and ELMO1 or ELMO2. Exchange of RAC1-bound GDP for GTP results in PTK6-induced RAC1 activation, which contributes to cell migration (Chen et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15572663	Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin Chen, HY, Shen, CH, Tsai, YT, Lin, FC, Huang, YP, Chen, RH	Mol. Cell. Biol.	2004