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Phosphorylated PXN recruits the CRK complex
Stable Identifier
R-HSA-8848611
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
Phosphorylated PXN recruits the CRK complex (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PXN (paxillin), phosphorylated by PTK6 (BRK) on tyrosine residues Y31 and Y118, recruits CRK (CrkII) complex which acts as a guanine exchange factor (GEF) for RAC1 (Chen et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
15572663
Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin
Huang, YP
,
Tsai, YT
,
Shen, CH
,
Lin, FC
,
Chen, HY
,
Chen, RH
Mol. Cell. Biol.
2004
Participants
Input
CRK:DOCK180:ELMO1,ELMO2 [cytosol]
(Homo sapiens)
p-Y31,Y118-PXN [cytosol]
(Homo sapiens)
Output
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol]
(Homo sapiens)
Participates
as an event of
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
Orthologous Events
Phosphorylated PXN recruits the CRK complex (Bos taurus)
Phosphorylated PXN recruits the CRK complex (Canis familiaris)
Phosphorylated PXN recruits the CRK complex (Drosophila melanogaster)
Phosphorylated PXN recruits the CRK complex (Gallus gallus)
Phosphorylated PXN recruits the CRK complex (Mus musculus)
Phosphorylated PXN recruits the CRK complex (Sus scrofa)
Authored
Orlic-Milacic, M (2016-01-05)
Reviewed
Pires, IM (2016-02-07)
Created
Orlic-Milacic, M (2015-12-10)
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