PTK6 phosphorylates PXN

Stable Identifier
R-HSA-8848606
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PTK6 phosphorylates PXN
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Activated PTK6 (BRK) phosphorylates PXN (paxillin) on tyrosine residues Y31 and Y118. PTK6-mediated phosphorylation of PXN can be triggered by EGF stimulation (Chen et al. 2004).

Literature References
PubMed ID Title Journal Year
15572663 Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

Chen, HY, Shen, CH, Tsai, YT, Lin, FC, Huang, YP, Chen, RH

Mol. Cell. Biol. 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y342-PTK6:PXN [cytosol]
Physical Entity
p-Y342-PTK6:PXN [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
PTK6 phosphorylates PXN (Bos taurus)
PTK6 phosphorylates PXN (Caenorhabditis elegans)
PTK6 phosphorylates PXN (Danio rerio)
PTK6 phosphorylates PXN (Drosophila melanogaster)
PTK6 phosphorylates PXN (Mus musculus)
PTK6 phosphorylates PXN (Rattus norvegicus)
PTK6 phosphorylates PXN (Sus scrofa)
PTK6 phosphorylates PXN (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-10)
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