Reactome | DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG

DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG

Stable Identifier

R-HSA-8848580

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG

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DGAT2L6 (Diacylglycerol O-acyltransferase 2-like protein 6, also known as DC3) catalyzes the transfer of an acyl group from acyl-CoA to DAG (diacylglycerol) to form TAG (triacylglycerol). DGAT2L6 catalyzes this reaction with low efficiency in vitro so its physiological role is uncertain. Based on its similarity to other proteins of the DGAT family it is inferred to be localized to the endoplasmic reticulum membrane (Turkish et al. 2005). The putative diacylglycerol O-acyltransferase 2-like protein DGAT2L7P may also possess the same activity as DGAT2L6.

Literature References

PubMed ID	Title	Journal	Year
15671038	Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily Bazzi, H, Billheimer, JT, Cromley, D, Turkish, AR, Sturley, SL, Oelkers, P, Henneberry, AL, Padamsee, M, Christiano, AM	J. Biol. Chem.	2005