DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG

Stable Identifier
Reaction [transition]
Homo sapiens
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DGAT2L6 (Diacylglycerol O-acyltransferase 2-like protein 6, also known as DC3) catalyzes the transfer of an acyl group from acyl-CoA to DAG (diacylglycerol) to form TAG (triacylglycerol). DGAT2L6 catalyzes this reaction with low efficiency in vitro so its physiological role is uncertain. Based on its similarity to other proteins of the DGAT family it is inferred to be localized to the endoplasmic reticulum membrane (Turkish et al. 2005). The putative diacylglycerol O-acyltransferase 2-like protein DGAT2L7P may also possess the same activity as DGAT2L6.

Literature References
PubMed ID Title Journal Year
15671038 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily

Bazzi, H, Billheimer, JT, Cromley, D, Turkish, AR, Sturley, SL, Oelkers, P, Henneberry, AL, Padamsee, M, Christiano, AM

J. Biol. Chem. 2005
Catalyst Activity

diacylglycerol O-acyltransferase activity of DGAT2L6 [endoplasmic reticulum membrane]

Orthologous Events
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