PLA2s hydrolyze phospholipids at the Golgi membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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Phospholipase A (PLA2) hydrolyzes the sn-2 position of phospholipids, releasing a fatty acid and a lysophospholipid (reviewed in Six and Dennis, 2000; Kudo and Murakami, 2002). A number studies have highlighted roles for a number of PLA2s in the maintenance of Golgi function and structure (de Figueiredo et al, 1998; de Figueiredo et al, 1999). PLAs may generate phospholipid and fatty acid products that recruit effectors of Golgi function and trafficking to the membrane or that affect downstream signaling pathways. Alternately, PLA2s may contribute directly to tubule formation at the Golgi through the production of the membrane-curvature inducing lysophospholipid (reviewed in Bechler et al, 2012). PLA2s may be recruited to the Golgi in response to changes in Ca2+ and/or cargo concentration that occur as a result of secretory traffic (Micaroni et al, 2010; San Pietro et al, 2009; Pulvirenti et al, 2008).
Literature References
PubMed ID Title Journal Year
22130221 A PLA1-2 punch regulates the Golgi complex

Bechler, ME, Brown, WJ, de Figueiredo, P

Trends Cell Biol. 2012
20420828 Synchronous intra-Golgi transport induces the release of Ca2+ from the Golgi apparatus

Mironov, AA, Di Giandomenico, D, Micaroni, M, Spaar, A, Perinetti, G, Bianchi, K

Exp. Cell Res. 2010
19753100 Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport

Tete, S, Trucco, A, Corda, D, Leslie, CC, Mariggi├▓, S, San Pietro, E, Sallese, M, DiPentima, A, Polishchuk, EV, Zizza, P, Mironov, AA, Pulvirenti, T, Polishchuk, RS, Capestrano, M, Luini, A

PLoS Biol. 2009
9671731 Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation

Drecktrah, D, Katzenellenbogen, JA, Strang, M, Brown, WJ, de Figueiredo, P

Proc. Natl. Acad. Sci. U.S.A. 1998
10359595 Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists

Drecktrah, D, Polizotto, RS, Brown, WJ, de Figueiredo, P

Mol. Biol. Cell 1999
11080672 The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

Six, DA, Dennis, EA

Biochim. Biophys. Acta 2000
18641641 A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway

San Pietro, E, Giannotta, M, Pisanu, A, Sallese, M, Beznoussenko, GV, Mironov, AA, Capitani, M, Turacchio, G, Pulvirenti, T, Polishchuk, RS, Capestrano, M, Luini, A, Hsu, VW

Nat. Cell Biol. 2008
12432908 Phospholipase A2 enzymes

Murakami, M, Kudo, I

Prostaglandins Other Lipid Mediat. 2002
Catalyst Activity

phospholipase A2 activity of cPLA2s [cytosol]

Orthologous Events
Cross References
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