IL18:IL18R1 binds IL18RAP

Stable Identifier
R-HSA-8848395
Type
Reaction [binding]
Species
Homo sapiens
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Interleukin-18/Interleukin-18 receptor 1 (IL18:IL18R1) complex binds Interleukin-18 receptor accessory protein (IL18RAP, IL18 receptor beta chain), forming a high-affinity signaling complex (Born et al. 1998, Debets et al. 2001). This IL18RAP subunit seems to be necessary for the signal transduction (Kim et al. 2001).

Literature References
PubMed ID Title Journal Year
9792649 Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling

Born, TL, Thomassen, E, Bird, TA, Sims, JE

J. Biol. Chem. 1998
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