Reactome | PNPLA4 hydrolyzes retinyl palmitate

PNPLA4 hydrolyzes retinyl palmitate

Stable Identifier

R-HSA-8848355

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

all-trans-retinyl hexadecanoate + H2O => all-trans-retinol + hexadecanoate + H(+)

ReviewStatus

5/5

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PNPLA4 (patatin-like phospholipase domain-containing protein 4, also known as GS2 and iPLA2(eta)) catalyzes the hydrolysis of atR-PALM (all-trans retinyl palmitate) to atROL (all-trans retinol) and a molecule of PALM (palmitate) (Gao and Simon 2006; Gao and Simon 2007). The reaction is inhibited by cytosolic PLIN3 (perilipin 3). The enzyme may also catalyze transacylation reactions to form retinyl esters or promote the activity of other enzymes that do so (Gao et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
16741517	Molecular screening for GS2 lipase regulators: inhibition of keratinocyte retinylester hydrolysis by TIP47 Gao, JG, Simon, M	J. Invest. Dermatol.	2006
19181555	GS2 as a retinol transacylase and as a catalytic dyad independent regulator of retinylester accretion Gao, JG, Shih, A, Gruber, R, Schmuth, M, Simon, M	Mol. Genet. Metab.	2009
17603008	A comparative study of human GS2, its paralogues, and its rat orthologue Gao, JG, Simon, M	Biochem. Biophys. Res. Commun.	2007