PNPLA5 hydrolyzes TAG

Stable Identifier
R-HSA-8848339
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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PNPLA5 hydrolyzes TAG
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PNPLA5 (patatin-like phospholipase domain-containing protein 5, also known as GS2 like) catalyzes the hydrolysis of TAG (triacylglycerol) to DAG (diacylglycerol) and one molecule of LCFA (long chain fatty acid) (Gao and Simon 2007).
Literature References
PubMed ID Title Journal Year
17603008 A comparative study of human GS2, its paralogues, and its rat orthologue

Simon, M, Gao, JG

Biochem. Biophys. Res. Commun. 2007
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Output
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Catalyst Activity

triacylglycerol lipase activity of PNPLA5 [cytosol]

Physical Entity
PNPLA5 [cytosol] (Homo sapiens)
Activity
triacylglycerol lipase activity (GO:0004806)
Orthologous Events
PNPLA5 hydrolyzes TAG (Caenorhabditis elegans)
PNPLA5 hydrolyzes TAG (Canis familiaris)
PNPLA5 hydrolyzes TAG (Danio rerio)
PNPLA5 hydrolyzes TAG (Drosophila melanogaster)
PNPLA5 hydrolyzes TAG (Gallus gallus)
PNPLA5 hydrolyzes TAG (Mus musculus)
PNPLA5 hydrolyzes TAG (Plasmodium falciparum)
PNPLA5 hydrolyzes TAG (Rattus norvegicus)
PNPLA5 hydrolyzes TAG (Xenopus tropicalis)
Authored
D'Eustachio, P  (2015-12-08)
Reviewed
Jassal, B  (2016-01-29)
Created
D'Eustachio, P  (2015-12-08)
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