PNPLA4 (patatin-like phospholipase domain-containing protein 4, also known as GS2 and iPLA2(eta)) catalyzes the hydrolysis of TAG (triacylglycerol) to DAG (diacylglycerol) and one molecule of LCFA (long chain fatty acid). The enzyme also has transacylase activity not annotated here (Gao and Simon 2007; Jenkins et al. 2004).
Gao, JG, Simon, M
Jenkins, CM, Mancuso, DJ, Yan, W, Sims, HF, Gibson, B, Gross, RW
triglyceride lipase activity of PNPLA4 [cytosol]
© 2021 Reactome
