PNPLA4 hydrolyzes TAG

Stable Identifier
R-HSA-8848338
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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PNPLA4 hydrolyzes TAG
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PNPLA4 (patatin-like phospholipase domain-containing protein 4, also known as GS2 and iPLA2(eta)) catalyzes the hydrolysis of TAG (triacylglycerol) to DAG (diacylglycerol) and one molecule of LCFA (long chain fatty acid). The enzyme also has transacylase activity not annotated here (Gao and Simon 2007; Jenkins et al. 2004).
Literature References
PubMed ID Title Journal Year
15364929 Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

Gibson, B, Yan, W, Sims, HF, Gross, RW, Jenkins, CM, Mancuso, DJ

J Biol Chem 2004
17603008 A comparative study of human GS2, its paralogues, and its rat orthologue

Simon, M, Gao, JG

Biochem. Biophys. Res. Commun. 2007
Participants
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Output
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as an event of
Catalyst Activity

triacylglycerol lipase activity of PNPLA4 [cytosol]

Physical Entity
PNPLA4 [cytosol] (Homo sapiens)
Activity
triacylglycerol lipase activity (GO:0004806)
Orthologous Events
PNPLA4 hydrolyzes TAG (Bos taurus)
PNPLA4 hydrolyzes TAG (Canis familiaris)
PNPLA4 hydrolyzes TAG (Gallus gallus)
PNPLA4 hydrolyzes TAG (Plasmodium falciparum)
PNPLA4 hydrolyzes TAG (Rattus norvegicus)
PNPLA4 hydrolyzes TAG (Sus scrofa)
PNPLA4 hydrolyzes TAG (Xenopus tropicalis)
Authored
D'Eustachio, P  (2015-12-08)
Reviewed
Jassal, B  (2016-01-29)
Created
D'Eustachio, P  (2015-12-08)
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