Reactome | IL37 binds IL18R1

IL37 binds IL18R1

Stable Identifier

R-HSA-8848335

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

IL-37 binds IL-18R1

ReviewStatus

5/5

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Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1F7) is a member of the IL-1 family. There are five isoforms of IL37 (a e) of which transcript IL-37 is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. Like several other IL-1 family members, IL-37 is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function. (Kumar et al. 2002). Both full length and processed IL-37 can bind the Interleukin 18 receptor 1 (IL-18R1) but binding of processed IL-37 is more effective (Shi et al. 2003, Kumar et al. 2002). Subsequently, Single Ig IL-1 related receptor (SIGIRR, TIR 8,IL-1R8) is recruited and facilitates the suppression of cytokine production in several types of immune cells resulting in reduced inflammation.

Literature References

PubMed ID	Title	Journal	Year
18390730	The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines Dinarello, CA, Sharma, S, Bufler, P, Reinhardt, D, Kim, SH, Gräf, R, Nold, MF, Kulk, N	J. Immunol.	2008
12809600	Mechanisms of TGF-beta signaling from cell membrane to the nucleus Massague, J, Shi, Y	Cell	2003
12096920	Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production Brigham-Burke, MR, Rieman, DJ, Kumar, S, Gambotto, A, Lotze, MT, Lehr, R, Kirkpatrick, RB, Lee, JC, Khandekar, S, Lynch, FJ, Hanning, CR, Scott, GF, Gao, W	Cytokine	2002