Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1F7) is a member of the IL-1 family. There are five isoforms of IL37 (a e) of which transcript IL-37 is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. Like several other IL-1 family members, IL-37 is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function. (Kumar et al. 2002). Both full length and processed IL-37 can bind the Interleukin 18 receptor 1 (IL-18R1) but binding of processed IL-37 is more effective (Shi et al. 2003, Kumar et al. 2002). Subsequently, Single Ig IL-1 related receptor (SIGIRR, TIR 8,IL-1R8) is recruited and facilitates the suppression of cytokine production in several types of immune cells resulting in reduced inflammation.
Dinarello, CA, Sharma, S, Bufler, P, Reinhardt, D, Kim, SH, Gräf, R, Nold, MF, Kulk, N
Massague, J, Shi, Y
Brigham-Burke, MR, Rieman, DJ, Kumar, S, Gambotto, A, Lotze, MT, Lehr, R, Kirkpatrick, RB, Lee, JC, Khandekar, S, Lynch, FJ, Hanning, CR, Scott, GF, Gao, W
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