Reactome | IL36 binds IL1RL2

IL36 binds IL1RL2

Stable Identifier

R-HSA-8848316

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

IL1RL2 binds interleukin-36

ReviewStatus

5/5

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Interleukin-1 receptor-like 2 (IL1RL2) is a receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 IL1RL2 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. IL1RL2 also binds Interleukin-1 family member 10 (IL38, IL1F10) (van de Veerdonk et al. 2012). The biological function of IL1F10 is thought to be inhibition of IL36 binding to IL36R (Yuan et al. 2015, Yi et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
11466363	Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2 Lo, S, Zurawski, S, Clifford, T, Kastelein, RA, Bazan, JF, Edwards, G, Sana, TR, Homey, B, Timans, JC, Wagner, J, Debets, R, Menon, S	J. Immunol.	2001
25673295	Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions Towne, JE, Gabay, C	J. Leukoc. Biol.	2015
22315422	IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist Dinarello, CA, Netea, MG, Azam, T, Wu, G, van de Veerdonk, FL, Hao, R, Kalabokis, V, Joosten, LA, Stoeckman, AK, van der Meer, JW, Boeckermann, AN	Proc. Natl. Acad. Sci. U.S.A.	2012