IL36 binds IL1RL2

Stable Identifier
R-HSA-8848316
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
IL1RL2 binds interleukin-36
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Interleukin-1 receptor-like 2 (IL1RL2) is a receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 IL1RL2 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. IL1RL2 also binds Interleukin-1 family member 10 (IL38, IL1F10) (van de Veerdonk et al. 2012). The biological function of IL1F10 is thought to be inhibition of IL36 binding to IL36R (Yuan et al. 2015, Yi et al. 2016).

Literature References
PubMed ID Title Journal Year
25673295 Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions

Gabay, C, Towne, JE

J. Leukoc. Biol. 2015
11466363 Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2

Debets, R, Timans, JC, Homey, B, Zurawski, S, Sana, TR, Lo, S, Wagner, J, Edwards, G, Clifford, T, Menon, S, Bazan, JF, Kastelein, RA

J. Immunol. 2001
22315422 IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

van de Veerdonk, FL, Stoeckman, AK, Wu, G, Boeckermann, AN, Azam, T, Netea, MG, Joosten, LA, van der Meer, JW, Hao, R, Kalabokis, V, Dinarello, CA

Proc. Natl. Acad. Sci. U.S.A. 2012
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