Reactome | IL36:IL1RL2 binds IL1RAP-1

IL36:IL1RL2 binds IL1RAP-1

Stable Identifier

R-HSA-8848314

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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After binding of IL36 to IL1RL2, the complex associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system (Gresnigt & van de Veerdonk 2013).

Literature References

PubMed ID	Title	Journal	Year
14734551	Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs Towne, JE, Sims, JE, Virca, GD, Renshaw, BR, Garka, KE	J. Biol. Chem.	2004