IL36:IL1RL2 binds IL1RAP-1

Stable Identifier
R-HSA-8848314
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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IL36:IL1RL2 binds IL1RAP-1
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After binding of IL36 to IL1RL2, the complex associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system (Gresnigt & van de Veerdonk 2013).
Literature References
PubMed ID Title Journal Year
14734551 Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs

Towne, JE, Sims, JE, Virca, GD, Renshaw, BR, Garka, KE

J. Biol. Chem. 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
IL36RN,IL1F10:IL1RL2 [plasma membrane] (Homo sapiens)
Orthologous Events
IL36:IL1RL2 binds IL1RAP-1 (Bos taurus)
IL36:IL1RL2 binds IL1RAP-1 (Canis familiaris)
IL36:IL1RL2 binds IL1RAP-1 (Mus musculus)
IL36:IL1RL2 binds IL1RAP-1 (Rattus norvegicus)
IL36:IL1RL2 binds IL1RAP-1 (Xenopus tropicalis)
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2015-12-07)
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