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ACBD6 binds LCFA-CoA
Stable Identifier
R-HSA-8848250
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Mitochondrial Fatty Acid Beta-Oxidation (Homo sapiens)
ACBD6 binds LCFA-CoA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Acyl-CoA-binding domain-containing protein 6 (ACBD6) has an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. ACBD6 binds long-chain acyl-CoAs (LCFA-CoA) with a strong preference for unsaturated, C18:1-CoA and C20:4-CoA, over saturated, C16:0-CoA substrates. ACBD6 is expressed in tissues and progenitor cells with functions in blood and vessel development (Soupene et al. 2008). A possible role of ACBD6 could be to protect membrane systems from the detergent nature of free acyl-CoAs by controlling their release to acyl-CoA-utilising enzymes (Soupene & Kuypers 2015).
Literature References
PubMed ID
Title
Journal
Year
26290611
Ligand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes
Kuypers, FA
,
Soupene, E
J. Lipid Res.
2015
18268358
Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells
Kuypers, FA
,
Soupene, E
,
Serikov, V
J. Lipid Res.
2008
Participants
Input
ACBD6 [cytosol]
(Homo sapiens)
LCFA-CoA [cytosol]
Output
ACBD6:LCFA-CoA [cytosol]
(Homo sapiens)
Participates
as an event of
Mitochondrial Fatty Acid Beta-Oxidation (Homo sapiens)
Event Information
Go Biological Process
acyl-CoA metabolic process (0006637)
Orthologous Events
ACBD6 binds LCFA-CoA (Bos taurus)
ACBD6 binds LCFA-CoA (Caenorhabditis elegans)
ACBD6 binds LCFA-CoA (Canis familiaris)
ACBD6 binds LCFA-CoA (Danio rerio)
ACBD6 binds LCFA-CoA (Dictyostelium discoideum)
ACBD6 binds LCFA-CoA (Drosophila melanogaster)
ACBD6 binds LCFA-CoA (Gallus gallus)
ACBD6 binds LCFA-CoA (Mus musculus)
ACBD6 binds LCFA-CoA (Plasmodium falciparum)
ACBD6 binds LCFA-CoA (Rattus norvegicus)
ACBD6 binds LCFA-CoA (Sus scrofa)
ACBD6 binds LCFA-CoA (Xenopus tropicalis)
Authored
Jassal, B (2015-12-07)
Reviewed
D'Eustachio, P (2016-04-05)
Created
Jassal, B (2015-12-07)
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