The selective autophagy of peroxisomes (pexophagy) is controlled by autophagy receptors through the assembly of a receptor protein complex (RPC). These receptors can recruit specific proteins required for pexophagy to occur. The human orthologue of the fungal acyl-CoA-binding protein Atg37, ACBD5, is a positive regulator of the pexophagic RPC process. Palmitoyl-CoA competes with autophagy receptors thus may affect the pexophagic RPC process. Acyl-CoA-binding domain-containing proteins 4 and 5 (ACBD4,5) are peroxisomal membrane-bound proteins and thought to bind medium- and long-chain acyl-CoA esters (MCFA-CoA, LCFA-CoA) (Nazarko et al. 2014, Nazarko 2014). The function of ACBD4 has not yet been determined.
Nazarko, TY
Subramani, S, Nazarko, TY, Lotfi, P, Ozeki, K, Yan, M, Ramakrishnan, G, Till, A
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