ACBD4,5 bind MCFA-CoA and LCFA-CoA

Stable Identifier
R-HSA-8848247
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The selective autophagy of peroxisomes (pexophagy) is controlled by autophagy receptors through the assembly of a receptor protein complex (RPC). These receptors can recruit specific proteins required for pexophagy to occur. The human orthologue of the fungal acyl-CoA-binding protein Atg37, ACBD5, is a positive regulator of the pexophagic RPC process. Palmitoyl-CoA competes with autophagy receptors thus may affect the pexophagic RPC process. Acyl-CoA-binding domain-containing proteins 4 and 5 (ACBD4,5) are peroxisomal membrane-bound proteins and thought to bind medium- and long-chain acyl-CoA esters (MCFA-CoA, LCFA-CoA) (Nazarko et al. 2014, Nazarko 2014). The function of ACBD4 has not yet been determined.

Literature References
PubMed ID Title Journal Year
24535825 Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy

Nazarko, TY, Ozeki, K, Till, A, Ramakrishnan, G, Lotfi, P, Yan, M, Subramani, S

J. Cell Biol. 2014
24905344 Atg37 regulates the assembly of the pexophagic receptor protein complex

Nazarko, TY

Autophagy 2014
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created