Reactome | ACBD4,5 bind MCFA-CoA and LCFA-CoA

ACBD4,5 bind MCFA-CoA and LCFA-CoA

Stable Identifier

R-HSA-8848247

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal membrane, peroxisomal matrix

ReviewStatus

5/5

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The selective autophagy of peroxisomes (pexophagy) is controlled by autophagy receptors through the assembly of a receptor protein complex (RPC). These receptors can recruit specific proteins required for pexophagy to occur. The human orthologue of the fungal acyl-CoA-binding protein Atg37, ACBD5, is a positive regulator of the pexophagic RPC process. Palmitoyl-CoA competes with autophagy receptors thus may affect the pexophagic RPC process. Acyl-CoA-binding domain-containing proteins 4 and 5 (ACBD4,5) are peroxisomal membrane-bound proteins and thought to bind medium- and long-chain acyl-CoA esters (MCFA-CoA, LCFA-CoA) (Nazarko et al. 2014, Nazarko 2014). The function of ACBD4 has not yet been determined.

Literature References

PubMed ID	Title	Journal	Year
24905344	Atg37 regulates the assembly of the pexophagic receptor protein complex Nazarko, TY	Autophagy	2014
24535825	Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy Subramani, S, Nazarko, TY, Lotfi, P, Ozeki, K, Yan, M, Ramakrishnan, G, Till, A	J. Cell Biol.	2014