The selective autophagy of peroxisomes (pexophagy) is controlled by autophagy receptors through the assembly of a receptor protein complex (RPC). These receptors can recruit specific proteins required for pexophagy to occur. The human orthologue of the fungal acyl-CoA-binding protein Atg37, ACBD5, is a positive regulator of the pexophagic RPC process. Palmitoyl-CoA competes with autophagy receptors thus may affect the pexophagic RPC process. Acyl-CoA-binding domain-containing proteins 4 and 5 (ACBD4,5) are peroxisomal membrane-bound proteins and thought to bind medium- and long-chain acyl-CoA esters (MCFA-CoA, LCFA-CoA) (Nazarko et al. 2014, Nazarko 2014). The function of ACBD4 has not yet been determined.
Nazarko, TY, Ozeki, K, Till, A, Ramakrishnan, G, Lotfi, P, Yan, M, Subramani, S
Nazarko, TY
© 2021 Reactome
