Reactome | ACBD4,5 bind MCFA-CoA and LCFA-CoA

ACBD4,5 bind MCFA-CoA and LCFA-CoA

Stable Identifier

R-HSA-8848247

Type

Reaction [binding]

Species

Homo sapiens

Compartment

peroxisomal membrane, peroxisomal matrix

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The selective autophagy of peroxisomes (pexophagy) is controlled by autophagy receptors through the assembly of a receptor protein complex (RPC). These receptors can recruit specific proteins required for pexophagy to occur. The human orthologue of the fungal acyl-CoA-binding protein Atg37, ACBD5, is a positive regulator of the pexophagic RPC process. Palmitoyl-CoA competes with autophagy receptors thus may affect the pexophagic RPC process. Acyl-CoA-binding domain-containing proteins 4 and 5 (ACBD4,5) are peroxisomal membrane-bound proteins and thought to bind medium- and long-chain acyl-CoA esters (MCFA-CoA, LCFA-CoA) (Nazarko et al. 2014, Nazarko 2014). The function of ACBD4 has not yet been determined.

Literature References

PubMed ID	Title	Journal	Year
24535825	Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy Nazarko, TY, Ozeki, K, Till, A, Ramakrishnan, G, Lotfi, P, Yan, M, Subramani, S	J. Cell Biol.	2014
24905344	Atg37 regulates the assembly of the pexophagic receptor protein complex Nazarko, TY	Autophagy	2014