DBI, ACBD7 bind MCFA-CoA and LCFA-CoA

Stable Identifier
R-HSA-8848246
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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DBI, ACBD7 bind MCFA-CoA and LCFA-CoA
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Acyl-CoA-binding protein (DBI, aka ACBP) can bind medium- and long-chain acyl-CoA esters (MCFA-CoA, LCFA-CoA) with very high affinity. It is localised to the ER (and Golgi) and may function as an intracellular carrier of acyl-CoA esters (Hansen et al. 2008, Bloksgaard et al. 2014). Acyl-CoA-binding domain-containing protein 7 (ACBD7) shares around 60% sequence homology with DBI and is proposed to also bind fatty acyl-CoAs but its function is yet to be determined.
Literature References
PubMed ID Title Journal Year
17953517 Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells

Hansen, JS, Faergeman, NJ, Kragelund, BB, Knudsen, J

Biochem. J. 2008
24080521 Acyl-CoA binding protein and epidermal barrier function

Bloksgaard, M, Neess, D, Færgeman, NJ, Mandrup, S

Biochim. Biophys. Acta 2014
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
acyl-CoA metabolic process (0006637)
Orthologous Events
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Bos taurus)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Caenorhabditis elegans)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Canis familiaris)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Danio rerio)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Dictyostelium discoideum)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Gallus gallus)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Mus musculus)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Plasmodium falciparum)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Saccharomyces cerevisiae)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Schizosaccharomyces pombe)
DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Xenopus tropicalis)
Authored
Jassal, B  (2015-12-07)
Reviewed
D'Eustachio, P  (2016-04-05)
Created
Jassal, B  (2015-12-07)
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