Reactome | RNU12 gene [nucleoplasm]

RNU12 gene [nucleoplasm]

Stable Identifier

R-HSA-8848189

Type

DNA Sequence [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U12 snRNA gene

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
    - General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
    - POU2F1 (OCT1) or POU2F2 (OCT2), SP1, and ZNF143 (STAF) bind the DSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
      - POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
    - SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
      - POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)
      - SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
        
        U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)
        
        RNU12 gene [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

ENSEMBL:ENSG00000276027 RNU12

Gene Names

RNU12

Participates

as a member of

U1,U2,U4,U4atac,U5,U11,U12 gene [nucleoplasm] (Homo sapiens)

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