STAT3 stimulates SOCS3 expression

Stable Identifier
R-HSA-8848178
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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STAT3 stimulates SOCS3 expression
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Binding of STAT3 to STAT response elements (SREs) in the promoter of the SOCS3 gene stimulates SOCS3 transcription (Yang et al. 2010, Wiejak et al. 2012).
Literature References
PubMed ID Title Journal Year
22311708 Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors

Wiejak, J, Dunlop, J, Gao, S, Borland, G, Yarwood, SJ

Mol. Pharmacol. 2012
21098664 Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

Yang, J, Huang, J, Dasgupta, M, Sears, N, Miyagi, M, Wang, B, Chance, MR, Chen, X, Du, Y, Wang, Y, An, L, Wang, Q, Lu, T, Zhang, X, Wang, Z, Stark, GR

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-Y705-STAT3 dimer:SOCS3 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-Y705-STAT3 dimer [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-05)
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