STAT3 stimulates SOCS3 expression

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Reaction [BlackBoxEvent]
Homo sapiens
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Binding of STAT3 to STAT response elements (SREs) in the promoter of the SOCS3 gene stimulates SOCS3 transcription (Yang et al. 2010, Wiejak et al. 2012).

Literature References
PubMed ID Title Journal Year
21098664 Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

Yang, J, Huang, J, Dasgupta, M, Sears, N, Miyagi, M, Wang, B, Chance, MR, Chen, X, Du, Y, Wang, Y, An, L, Wang, Q, Lu, T, Zhang, X, Wang, Z, Stark, GR

Proc. Natl. Acad. Sci. U.S.A. 2010
22311708 Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors

Wiejak, J, Dunlop, J, Gao, S, Borland, G, Yarwood, SJ

Mol. Pharmacol. 2012
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