STAT3 binds SOCS3 promoter

Stable Identifier
R-HSA-8848150
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
STAT3 binds SOCS3 promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The promoter of the SOCS3 gene contains two STAT binding/response elements (SREs), in between the AP-1 site and the SP1/SP3 site. STAT3, the AP-1 (FOS:JUN) complex and SP1 or SP3 can all contribute to SOCS3 induction (Wiejak et al. 2012), which depends on the cellular context. In some cell types, binding of STAT3 may be necessary (Isobe et al. 2006) for stimulation of SOCS3 transcription. STAT1 but not STAT3 is important for SOCS3 induction downstream of interferon-gamma (IFNG) signaling (Gatto et al. 2004). STAT3 needs to be phosphorylated on tyrosine residue Y705 in order to bind the SOCS3 promoter and activate SOCS3 transcription (Yang et al. 2010).

Literature References
PubMed ID Title Journal Year
21098664 Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

Yang, J, Huang, J, Dasgupta, M, Sears, N, Miyagi, M, Wang, B, Chance, MR, Chen, X, Du, Y, Wang, Y, An, L, Wang, Q, Lu, T, Zhang, X, Wang, Z, Stark, GR

Proc. Natl. Acad. Sci. U.S.A. 2010
22311708 Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors

Wiejak, J, Dunlop, J, Gao, S, Borland, G, Yarwood, SJ

Mol. Pharmacol. 2012
16300827 STAT3-mediated constitutive expression of SOCS3 in an undifferentiated rat trophoblast-like cell line

Isobe, A, Takeda, T, Sakata, M, Yamamoto, T, Minekawa, R, Hayashi, M, Auernhammer, CJ, Tasaka, K, Murata, Y

Placenta 2006
Participants
Input
Output
Participant Of
hasEvent
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-05)