Activated PTK6 (BRK) phosphorylates STAT3 on tyrosine residue Y705. PTK6-mediated phosphorylation of STAT3 is promoted by STAP2 and inhibited by SOCS3 (Liu et al. 2006, Ikeda et al. 2010).
Ikeda, O, Sekine, Y, Mizushima, A, Nakasuji, M, Miyasaka, Y, Yamamoto, C, Muromoto, R, Nanbo, A, Oritani, K, Yoshimura, A, Matsuda, T
Liu, L, Gao, Y, Qiu, H, Miller, WT, Poli, V, Reich, NC
protein tyrosine kinase activity of p-Y342-PTK6:p-Y250-STAP2:STAT3 [cytosol]
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