PTK6 phosphorylates STAT3

Stable Identifier
R-HSA-8848124
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PTK6 phosphorylates STAT3
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Activated PTK6 (BRK) phosphorylates STAT3 on tyrosine residue Y705. PTK6-mediated phosphorylation of STAT3 is promoted by STAP2 and inhibited by SOCS3 (Liu et al. 2006, Ikeda et al. 2010).

Literature References
PubMed ID Title Journal Year
20929863 Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells

Ikeda, O, Sekine, Y, Mizushima, A, Nakasuji, M, Miyasaka, Y, Yamamoto, C, Muromoto, R, Nanbo, A, Oritani, K, Yoshimura, A, Matsuda, T

J. Biol. Chem. 2010
16568091 Identification of STAT3 as a specific substrate of breast tumor kinase

Liu, L, Gao, Y, Qiu, H, Miller, WT, Poli, V, Reich, NC

Oncogene 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y342-PTK6:p-Y250-STAP2:STAT3 [cytosol]
Physical Entity
p-Y342-PTK6:p-Y250-STAP2:STAT3 [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
PTK6 phosphorylates STAT3 (Danio rerio)
PTK6 phosphorylates STAT3 (Mus musculus)
PTK6 phosphorylates STAT3 (Rattus norvegicus)
PTK6 phosphorylates STAT3 (Sus scrofa)
PTK6 phosphorylates STAT3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-05)