Reactome | STAP2 [cytosol]

STAP2 [cytosol]

Stable Identifier

R-HSA-8848028

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Signal-transducing adaptor protein 2, STAP-2, BRK substrate

Locations in the PathwayBrowser for interactor UniProt:P51451 BLK

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External Reference Information

External Reference

UniProt:Q9UGK3 STAP2

Gene Names

STAP2, BKS

Chain

chain:1-403

Reference Genes

BioGPS Gene:55620 STAP2

COSMIC (genes):STAP2 STAP2

CTD Gene:55620 STAP2

dbSNP Gene:55620 STAP2

ENSEMBL:ENSG00000178078 STAP2

ENSEMBL_homo_sapiens_GENE:ENSG00000178078.12 STAP2

HGNC:30430 STAP2

KEGG Gene (Homo sapiens):55620 STAP2

Monarch:55620 STAP2

NCBI Gene:55620 STAP2

OMIM:607881 STAP2

UCSC:Q9UGK3 STAP2

Reference Transcript

Other Identifiers

11721943_a_at

11736317_x_at

16867278

221610_PM_s_at

221610_s_at

3846710

3846711

3846712

3846713

3846714

3846715

3846716

3846717

3846718

3846719

3846720

3846722

3846724

3846726

3846727

3846728

3846730

55620

63788_at

8032789

GE87437

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0035591

GO:0060090

HMNXSV003024376

HMNXSV003036735

ILMN_1657631

ILMN_1704500

ILMN_2281529

ILMN_2384237

TC19001061.hg

g12653994_3p_a_at

Participates

as a component of

p-Y342-PTK6:STAP2 [cytosol] (Homo sapiens)

as an input of

Activated PTK6 binds STAP2 (Homo sapiens)

Other forms of this molecule

p-Y250-STAP2 [plasma membrane]

Inferred To

STAP2 [cytosol] (Bos taurus)

STAP2 [cytosol] (Sus scrofa)

Stap2 [cytosol] (Mus musculus)

Stap2 [cytosol] (Rattus norvegicus)

stap2a [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001013863.1, NP_060190.2

OpenTargets

ENSG00000178078

HPA

ENSG00000178078-STAP2

GeneCards

Q9UGK3

Ensembl

ENSP00000471052, ENSP00000468927, ENSG00000178078, ENST00000600324, ENST00000594605

PRO

Q9UGK3

Pharos - Targets

Q9UGK3

PDB

2EL8

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.623	7
UniProt:Q9ULC6 PADI1	2	PADI1 [cytosol] (R-HSA-1183112) PADI1 [nucleoplasm] (R-HSA-6793445)	0.589	2
UniProt:P42681 TXK	3	TXK [cytosol] (R-HSA-3448733) p-Y91,Y420-TXK [cytosol] (R-HSA-3448740) p-Y420-TXK [cytosol] (R-HSA-3448734)	0.556	3
UniProt:P42229 STAT5A	4	STAT5A [nucleoplasm] (R-HSA-9701901) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747)	0.556	11
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.556	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.556	3
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P51692 STAT5B	4	STAT5B [cytosol] (R-HSA-380737) p-Y699-STAT5B [cytosol] (R-HSA-507939) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016) p-STAT5B [cytosol] (R-HSA-8983127)	0.524	10
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.524	3

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