Reactome | Activated ERBB2 binds PTK6 (BRK)

Activated ERBB2 binds PTK6 (BRK)

Stable Identifier

R-HSA-8847995

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - ERBB2 Activates PTK6 Signaling (Homo sapiens)
      - Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by ERBB2 (Homo sapiens)
    - ERBB2 Activates PTK6 Signaling (Homo sapiens)
      - Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)

General

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SVG | | PPTX | SBGN

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PTK6 (BRK) is a nonreceptor tyrosine kinase that can bind activated ERBB2 receptor (Xiang et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18719096	Brk is coamplified with ErbB2 to promote proliferation in breast cancer Xiang, B, Chatti, K, Qiu, H, Lakshmi, B, Krasnitz, A, Hicks, J, Yu, M, Miller, WT, Muthuswamy, SK	Proc. Natl. Acad. Sci. U.S.A.	2008