Reactome | ALPP [transport vesicle]

ALPP [transport vesicle]

Stable Identifier

R-HSA-8847823

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

transport vesicle

Synonyms

Alkaline phosphatase, placental type, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Intra-Golgi traffic (Homo sapiens)
      - ARF1:GTP binds Golgin TRIP11 (Homo sapiens)
        
        ARF1:GTP:TRIP11:cargo [Golgi membrane] (Homo sapiens)
        
        TRIP11:cargo [transport vesicle] (Homo sapiens)
        
        cargo requiring TRIP11 for tethering [transport vesicle] (Homo sapiens)
        
        ALPP [transport vesicle] (Homo sapiens)
        
        TRIP11:cargo [transport vesicle] (Homo sapiens)
        
        cargo requiring TRIP11 for tethering [transport vesicle] (Homo sapiens)
        
        ALPP [transport vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05187 ALPP

Gene Names

ALPP, PLAP

Chain

signal peptide:1-22, chain:23-506, propeptide:507-535

Reference Genes

BioGPS Gene:250 ALPP

COSMIC (genes):ALPP ALPP

CTD Gene:250 ALPP

dbSNP Gene:250 ALPP

ENSEMBL:ENSG00000163283 ALPP

ENSEMBL_homo_sapiens_GENE:ENSG00000163283.7 ALPP

HGNC:439 ALPP

KEGG Gene (Homo sapiens):250 ALPP

Monarch:250 ALPP

NCBI Gene:250 ALPP

OMIM:171800 ALPP

UCSC:P05187 ALPP

Reference Transcript

RefSeq:NM_001632.4 ALPP

Other Identifiers

11723748_at

11752432_s_at

16892231

204664_PM_at

204664_at

211619_PM_s_at

211619_s_at

250

2532276

2532277

2532278

2532279

2532280

2532281

2532282

2532283

2532284

2532285

2532286

2532287

2532288

2532289

2532290

2532291

2532292

2532298

2532299

2532300

2532301

2532303

2532305

2532306

2532307

2532309

2532310

2532339

8049123

8180197

A_23_P68183

A_23_P79587

GE81048

GE86191

GO:0000287

GO:0003824

GO:0004035

GO:0005515

GO:0005886

GO:0008270

GO:0009986

GO:0016020

GO:0016311

GO:0016787

GO:0016791

GO:0046872

GO:0098552

HMNXSV003029853

HMNXSV003046281

Hs.284255.2.S1_3p_s_at

ILMN_1693789

M19159_at

PH_hs_0014727

TC02001398.hg

TC02001399.hg

g13787194_3p_at

g178471_3p_s_at

Participates

as a candidate of

cargo requiring TRIP11 for tethering [transport vesicle] (Homo sapiens)

Inferred To

ALPP [transport vesicle] (Canis familiaris)

ALPP [transport vesicle] (Drosophila melanogaster)

ALPP [transport vesicle] (Gallus gallus)

ALPP [transport vesicle] (Mus musculus)

ALPP [transport vesicle] (Rattus norvegicus)

ALPP [transport vesicle] (Sus scrofa)

ALPP [transport vesicle] (Xenopus tropicalis)

Homologues of ALPP [transport vesicle] (Drosophila melanogaster)

Homologues of ALPP [transport vesicle] (Mus musculus)

Homologues of ALPP [transport vesicle] (Rattus norvegicus)

Homologues of ALPP [transport vesicle] (Sus scrofa)

Cross References

RefSeq

NP_001623.3

OpenTargets

ENSG00000163283

IntEnz

3.1.3.1

HPA

ENSG00000163283-ALPP

GeneCards

P05187

ZINC target

P05187

Ensembl

ENST00000392027, ENSG00000163283, ENSP00000375881

PRO

P05187

Pharos - Targets

P05187

HMDB Protein

HMDBP00090

PDB

1EW2, 2GLQ, 3MK0, 1ZEF, 1ZEB, 3MK1, 3MK2, 1ZED

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92570 NR4A3	1	NR4A3 [nucleoplasm] (R-HSA-8938004)	0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	7
UniProt:P22735 TGM1	3	TGM1 [cytosol] (R-HSA-6813756) TGM1 [cornified envelope] (R-HSA-8847706) TGM1 [plasma membrane] (R-HSA-6813757)	0.556	3