Reactome | RAB43:GTP binds USP8NL

RAB43:GTP binds USP8NL

Stable Identifier

R-HSA-8847537

Type

Reaction [binding]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

ReviewStatus

5/5

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RAB43 contributes to the maintenance of Golgi structure and is required for the RAB6-dependent retrograde trafficking of Shiga toxin (Fuchs et al, 2007; Haas et al, 2007). RAB43 appears to be localized to the cis side of the Golgi, so the details of how and when it affects Shiga transport remain to be clarified (Dejgaard et al, 2007). Screens of human cells identified USP6NL as a RAB43-specific GTPase activating (GAP) protein that is also implicated in Shiga trafficking (Fuchs et al, 2007; Haas et al, 2007; reviewed in Pfeffer, 2011).

Literature References

PubMed ID	Title	Journal	Year
17562788	Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways Spooner, RA, Barr, FA, Lord, JM, Haas, AK, Yoshimura, S, Fuchs, E	J. Cell Biol.	2007
18664496	Rab18 and Rab43 have key roles in ER-Golgi trafficking Presley, JF, Verbich, D, Lodge, R, Murshid, A, Dejgaard, K, Kizilay, O, Simpson, JC, Pepperkok, R, Ly-Hartig, TB, Dejgaard, SY, Erman, A	J. Cell. Sci.	2008
21421921	Entry at the trans-face of the Golgi Pfeffer, SR	Cold Spring Harb Perspect Biol	2011
17684057	Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells Barr, FA, Haas, AK, Stephens, DJ, Yoshimura, S, Fuchs, E, Preisinger, C	J. Cell. Sci.	2007