Reactome | RAB43 hydrolyses GTP

RAB43 hydrolyses GTP

Stable Identifier

R-HSA-8847534

Type

Reaction [transition]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

ReviewStatus

5/5

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RAB GAP USP6NL stimulates the GTPase activity of RAB43, promoting hydrolysis of GTP. Both RAB43 and USP6NL have been identifed as contributing to the retrograde transport of Shiga toxin to the Golgi, however the details of their roles remain to be elucidated (Fuchs et al, 2007; Haas et al, 2007; reviewed in Pfeffer, 2011).

Literature References

PubMed ID	Title	Journal	Year
17562788	Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways Spooner, RA, Barr, FA, Lord, JM, Haas, AK, Yoshimura, S, Fuchs, E	J. Cell Biol.	2007
21421921	Entry at the trans-face of the Golgi Pfeffer, SR	Cold Spring Harb Perspect Biol	2011
17684057	Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells Barr, FA, Haas, AK, Stephens, DJ, Yoshimura, S, Fuchs, E, Preisinger, C	J. Cell. Sci.	2007