RAB43 hydrolyses GTP

Stable Identifier
Reaction [transition]
Homo sapiens
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RAB GAP USP6NL stimulates the GTPase activity of RAB43, promoting hydrolysis of GTP. Both RAB43 and USP6NL have been identifed as contributing to the retrograde transport of Shiga toxin to the Golgi, however the details of their roles remain to be elucidated (Fuchs et al, 2007; Haas et al, 2007; reviewed in Pfeffer, 2011).

Literature References
PubMed ID Title Journal Year
17562788 Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

Spooner, RA, Barr, FA, Lord, JM, Haas, AK, Yoshimura, S, Fuchs, E

J. Cell Biol. 2007
21421921 Entry at the trans-face of the Golgi

Pfeffer, SR

Cold Spring Harb Perspect Biol 2011
17684057 Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

Barr, FA, Haas, AK, Stephens, DJ, Yoshimura, S, Fuchs, E, Preisinger, C

J. Cell. Sci. 2007
Catalyst Activity

GTPase activity of RAB43:GTP:USP6NL [trans-Golgi network membrane]

Orthologous Events
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