Reactome | IL3 stimulation induces Vav binding to Tec kinase

IL3 stimulation induces Vav binding to Tec kinase

Stable Identifier

R-HSA-879914

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

IL3 stimulation induces Vav binding to Tec kinase

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

IL3 stimulation induces rapid and transient tyrosine-phosphorylation of Vav and the binding of Vav to Tec kinase through Tec homology domains. (Machide et al. 1995). Vav1 and Tec were seen to associate into a complex with the activated prolactin receptor (Kline et al. 2001). These reports were interpreted as Tec enhancing Vav GEF activity, but it has been suggested that Vav might contribute to Tec activation in T cell signaling (Reynolds et al. 2002). Tec kinases generally require PI3K-dependent membrane translocation and phosphorylation of the kinase domain, often by an Src family kinase, for activation (Takesono et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11328862	Activation and association of the Tec tyrosine kinase with the human prolactin receptor: mapping of a Tec/Vav1-receptor binding site Clevenger, CV, Moore, DJ, Kline, JB	Mol Endocrinol	2001
7651724	Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain Mano, H, Machide, M, Todokoro, K	Oncogene	1995