SLC27A1,4,6 transport LCFAs from extracellular region to cytosol

Stable Identifier
R-HSA-879585
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The SLC27 gene family code for fatty acid transporter proteins (FATPs). Of the six FATPs characterized, only three have been shown to mediate the influx of long chain fatty acids (LCFAs) into cells; FATP1, 4 and 6. They have been shown to transport the prototypical LCFA oleic acid (OLEA) but are believed to be able to transport LCFAs with chain lengths longer than 10 carbons. FATP1 is highly expressed in adipose tissue and muscle (Hatch GM et al, 2002). FATP4 is the major intestinal LCFA transporter (Fitscher BA et al, 1998; Stahl A et al, 1999). FATP6 is localized to cardiac myocytes (Gimeno RE et al, 2003).

Literature References
PubMed ID Title Journal Year
9878842 Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)

Fitscher, BA, Riedel, HD, Young, KC, Stremmel, W

Biochim Biophys Acta 1998
12556534 Characterization of a heart-specific fatty acid transport protein

Gimeno, RE, Ortegon, AM, Patel, S, Punreddy, S, Ge, P, Sun, Y, Lodish, HF, Stahl, A

J Biol Chem 2003
10518211 Identification of the major intestinal fatty acid transport protein

Stahl, A, Hirsch, DJ, Gimeno, RE, Punreddy, S, Ge, P, Watson, N, Patel, S, Kotler, M, Raimondi, A, Tartaglia, LA, Lodish, HF

Mol Cell 1999
12235169 FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells

Hatch, GM, Smith, AJ, Xu, FY, Hall, AM, Bernlohr, DA

J Lipid Res 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fatty acid transmembrane transporter activity of SLC27A1,4,6 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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