SLC27A1,4,6 transport LCFAs from extracellular region to cytosol

Stable Identifier
R-HSA-879585
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The SLC27 gene family code for fatty acid transporter proteins (FATPs). Of the six FATPs characterized, only three have been shown to mediate the influx of long chain fatty acids (LCFAs) into cells; FATP1, 4 and 6. They have been shown to transport the prototypical LCFA oleic acid (OLEA) but are believed to be able to transport LCFAs with chain lengths longer than 10 carbons. FATP1 is highly expressed in adipose tissue and muscle (Hatch GM et al, 2002). FATP4 is the major intestinal LCFA transporter (Fitscher BA et al, 1998; Stahl A et al, 1999). FATP6 is localized to cardiac myocytes (Gimeno RE et al, 2003).
Literature References
PubMed ID Title Journal Year
12556534 Characterization of a heart-specific fatty acid transport protein

Punreddy, S, Ortegon, AM, Gimeno, RE, Ge, P, Sun, Y, Stahl, A, Lodish, HF, Patel, S

J Biol Chem 2003
9878842 Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)

Riedel, HD, Young, KC, Stremmel, W, Fitscher, BA

Biochim Biophys Acta 1998
10518211 Identification of the major intestinal fatty acid transport protein

Punreddy, S, Gimeno, RE, Hirsch, DJ, Ge, P, Raimondi, A, Tartaglia, LA, Watson, N, Kotler, M, Stahl, A, Lodish, HF, Patel, S

Mol Cell 1999
12235169 FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells

Hatch, GM, Smith, AJ, Bernlohr, DA, Xu, FY, Hall, AM

J Lipid Res 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

fatty acid transmembrane transporter activity of SLC27A1,4,6 [plasma membrane]

Physical Entity
SLC27A1,4,6 [plasma membrane] (Homo sapiens)
Activity
fatty acid transmembrane transporter activity (GO:0015245)
Orthologous Events
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Bos taurus)
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Caenorhabditis elegans)
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Canis familiaris)
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Danio rerio)
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Drosophila melanogaster)
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Gallus gallus)
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Mus musculus)
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Rattus norvegicus)
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Saccharomyces cerevisiae)
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Sus scrofa)
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Xenopus tropicalis)
Authored
Jassal, B  (2010-06-18)
Reviewed
He, L  (2010-07-07)
Created
Jassal, B  (2010-06-18)
Cite Us!