Reactome | Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor

Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor

Stable Identifier

R-HSA-879411

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor

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Advanced glycosylation end product specific receptor (AGER) also known as Receptor for advanced glycation end products (RAGE) is a multi-ligand membrane receptor belonging to the immunoglobulin superfamily. It recognizes a large variety of modified proteins known as advanced glycation/glycosylation endproducts (AGEs) a heterogenous group of structures (Ikeda et al. 1996) that accumulate in patients with diabetes, atherosclerosis, renal failure or ageing (Schmidt et al. 1999). The most prevalent class of AGE in vivo are N(6)-carboxymethyllysine (NECML) adducts (Kislinger et al. 1991). AGER is a receptor for amyloid-beta peptide (Ab)(Yan et al. 1996), mediating Ab neurotoxicity and promoting Ab influx into the brain (Zhang et al. 2009). AGER also responds to the proinflammatory S100/calgranulins (Hofmann et al. 1999) and High mobility group protein B1 (HMGB1/Amphoterin/DEF) (Hori et al. 1995). The major pathway is NFkappaB activation, but AGER can also activate rho-GTPases and thereby MAPK and JNK cascades. (Bierhaus et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
10531386	N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression Kislinger, T, Fu, C, Huber, B, Qu, W, Taguchi, A, Du Yan, S, Hofmann, M, Yan, SF, Pischetsrieder, M, Stern, D, Schmidt, AM	J Biol Chem	1999