Reactome | CAPZB [cytosol]

CAPZB [cytosol]

Stable Identifier

R-HSA-879409

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

F-actin-capping protein subunit beta, CAPZB_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q53GL0 PKHO1

Expand all

External Reference Information

External Reference

UniProt:P47756 CAPZB

Gene Names

CAPZB

Chain

initiator methionine:, chain:2-272

Reference Genes

BioGPS Gene:832 CAPZB

COSMIC (genes):CAPZB CAPZB

CTD Gene:832 CAPZB

dbSNP Gene:832 CAPZB

ENSEMBL:ENSG00000077549 CAPZB

ENSEMBL_homo_sapiens_GENE:ENSG00000077549.19 CAPZB

HGNC:1491 CAPZB

KEGG Gene (Homo sapiens):832 CAPZB

Monarch:832 CAPZB

NCBI Gene:832 CAPZB

OMIM:601572 CAPZB

UCSC:P47756 CAPZB

Reference Transcript

Other Identifiers

11720600_a_at

16682704

201949_3p_x_at

201949_PM_x_at

201949_x_at

201950_PM_x_at

201950_x_at

2399766

2399767

2399768

2399769

2399770

2399771

2399772

2399773

2399774

2399775

2399776

2399783

2399787

2399799

2399800

2399801

2399802

2399815

2399816

2399821

2399833

2399855

37012_PM_at

37012_at

4901305_3p_s_at

7913169

832

A_23_P126752

A_33_P3235562

A_33_P3235568

GE61350

GE85982

GO:0000902

GO:0003779

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0005903

GO:0005929

GO:0007010

GO:0008092

GO:0008154

GO:0008290

GO:0010591

GO:0014069

GO:0015629

GO:0016020

GO:0022604

GO:0030017

GO:0030027

GO:0030030

GO:0030032

GO:0030036

GO:0030863

GO:0032279

GO:0043226

GO:0045296

GO:0048856

GO:0051015

GO:0051016

GO:0051490

GO:0051693

GO:0065003

GO:0070062

GO:0071203

GO:0097224

GO:0098685

GO:0098686

HMNXSV003011056

Hs.76368.0.S2_3p_s_at

ILMN_2053921

PH_hs_0016331

TC01002300.hg

TC01005305.hg

g4826658_3p_s_at

Participates

as a candidate of

as an input of

F-actin capping protein is a heterodimer (Homo sapiens)

as a component of

Inferred To

CAP2 [cytosol] (Saccharomyces cerevisiae)

cpb [cytosol] (Drosophila melanogaster)

capzb [cytosol] (Xenopus tropicalis)

CAPZB [cytosol] (Bos taurus)

CAPZB [cytosol] (Canis familiaris)

CAPZB [cytosol] (Gallus gallus)

CAPZB [cytosol] (Plasmodium falciparum)

CAPZB [cytosol] (Sus scrofa)

acpA [cytosol] (Dictyostelium discoideum)

cap-2 [cytosol] (Caenorhabditis elegans)

Capzb [cytosol] (Mus musculus)

Capzb [cytosol] (Rattus norvegicus)

acp2 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001269091.1, NP_004921.1

OpenTargets

ENSG00000077549

HPA

ENSG00000077549-CAPZB

GeneCards

P47756

Ensembl

ENSP00000501528, ENSG00000077549, ENST00000264202, ENST00000375142, ENSP00000264202, ENSP00000364284, ENST00000674432

PRO

P47756

Pharos - Targets

P47756

PDB

8F8Q

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.725	6
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.725	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.725	23
UniProt:P52907 CAPZA1	2	CAPZA1 [cytosol] (R-HSA-879363) CAPZA1(265-276) [extracellular region] (R-HSA-879421)	0.669	4
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.643	5
UniProt:Q9C0C2 TNKS1BP1	1	TNKS1BP1 [cytosol] (R-HSA-430011)	0.643	5
UniProt:P23508 CRCM			0.564	2
UniProt:Q6IBS0 TWF2	1	TWF2 [cytosol] (R-HSA-9663291)	0.564	2
UniProt:P0DTD1-PRO_0000449628 REP			0.547	2
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.527	2
UniProt:O75175 CNOT3	1	CNOT3 [cytosol] (R-HSA-429872)	0.527	3
UniProt:Q92600 RQCD1	2	RQCD1 [cytosol] (R-HSA-430029) RQCD1 [nucleoplasm] (R-HSA-6810130)	0.527	3
UniProt:Q9H9A5 CNOT10	1	CNOT10 [cytosol] (R-HSA-429878)	0.527	3
UniProt:O95425 SVIL			0.527	3
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.527	3
UniProt:Q9Y4E1 WAC2C			0.527	3
UniProt:Q9Y3C0 WASC3			0.527	3
UniProt:Q12768 WASC5			0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:O75935 DCTN3	1	DCTN3 [cytosol] (R-HSA-380264)	0.527	3
UniProt:Q96LI5 CNOT6L	1	CNOT6L [cytosol] (R-HSA-430027)	0.527	3
UniProt:A5YKK6 CNOT1	1	CNOT1 [cytosol] (R-HSA-429892)	0.527	3
UniProt:Q6F5E8 CARL2			0.527	3
UniProt:Q96P48 ARAP1	2	ARAP1 [cytosol] (R-HSA-3211582) p-Y231-ARAP1 [cytosol] (R-HSA-8848869)	0.527	3
UniProt:Q9Y4B5 MTCL1			0.527	3
UniProt:P42025 ACTR1B	4	ACTR1B [cytosol] (R-HSA-2228745) ACTR1B [secretory granule lumen] (R-HSA-6801082) ACTR1B [extracellular region] (R-HSA-6806503) ACTR1B [ficolin-1-rich granule lumen] (R-HSA-6801063)	0.527	3
UniProt:P61163 ACTR1A	1	ACTR1A [cytosol] (R-HSA-380258)	0.527	3
UniProt:Q9Y3L3 SH3BP1	1	SH3BP1 [cytosol] (R-HSA-3006458)	0.527	3
UniProt:Q9ULM6 CNOT6	2	CNOT6 [nucleoplasm] (R-HSA-6810131) CNOT6 [cytosol] (R-HSA-429930)	0.527	3
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.527	2
UniProt:P47755 CAPZA2	2	CAPZA2(265-276) [extracellular region] (R-HSA-879417) CAPZA2 [cytosol] (R-HSA-879448)	0.527	4
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.527	3
UniProt:Q5VZK9 CARMIL1	1	LRRC16A [cytosol] (R-HSA-994131)	0.527	3
UniProt:Q9BTE1 DCTN5	1	DCTN5 [cytosol] (R-HSA-2029012)	0.527	4
UniProt:Q9UJW0 DCTN4	1	DCTN4 [cytosol] (R-HSA-2029070)	0.527	3
UniProt:O00399 DCTN6	1	DCTN6 [cytosol] (R-HSA-2029035)	0.527	3
UniProt:P58546 MTPN			0.527	2
UniProt:Q9ULJ8 NEB1			0.527	2
UniProt:Q53GL0 PKHO1			0.527	3
UniProt:Q9H3G5 CPVL			0.527	2
UniProt:Q9UFF9 CNOT8	1	CNOT8 [cytosol] (R-HSA-429979)	0.527	2
UniProt:Q6ZU35 CRACD			0.527	3
UniProt:Q8TD55 PLEKHO2	2	PLEKHO2 [extracellular region] (R-HSA-6806484) PLEKHO2 [ficolin-1-rich granule lumen] (R-HSA-6801067)	0.527	3
UniProt:Q9NZN8 CNOT2	1	CNOT2 [cytosol] (R-HSA-429902)	0.527	3
UniProt:Q2M389 WASC4			0.527	3
UniProt:Q12792 TWF1	1	TWF1 [cytosol] (R-HSA-9667687)	0.527	2
UniProt:Q9BY89 K1671			0.527	3
UniProt:Q9NZ32 ACTR10	4	ACTR10 [azurophil granule lumen] (R-HSA-6801080) ACTR10 [extracellular region] (R-HSA-6806245) ACTR10 [ficolin-1-rich granule lumen] (R-HSA-6801072) ACTR10 [cytosol] (R-HSA-6801556)	0.527	3
UniProt:Q641Q2 WAC2A			0.527	2
UniProt:Q9UKZ1 CNOT11	1	CNOT11 [cytosol] (R-HSA-429981)	0.527	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2
UniProt:Q9UIV1 CNOT7	1	CNOT7 [cytosol] (R-HSA-429877)	0.527	3
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2

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