Reactome | AGER-1,2,3 bind AGEs

AGER-1,2,3 bind AGEs

Stable Identifier

R-HSA-879358

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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In addition to AGER/RAGE, several other proteins have been identified as AGE-binding proteins. AGE binding proteins p60 and p90 (Yang et al. 1991) were subsequently identified as the Oligosaccharyl transferase 48 kDa subunit (Ost-48) and Glucosidease-2 subunit beta (Li et al. 1996). A third member was identified as Galectin-3 (Vlassara et al. 1995). These 3 proteins have been shown to be present on the plasma membrane of many cell types including vascular endothelium (Stitt et al. 1999). They have been designated AGE-R1, -R2 and -R3. Their suggested function is the removal and degradation of AGEs, but AGER-1 was found to negatively regulate AGER/RAGE (Lu et al. 2004), with kinetics that suggested a more complex interaction than simple competition for the same ligand.

Literature References

PubMed ID	Title	Journal	Year
8529130	Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex Cerami, A, Imani, F, Liu, FT, Yang, Z, Wojciechowicz, D, Vlassara, H, Li, YM	Mol Med	1995
1651976	Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins Brunelle, S, Suthanthiran, M, Cerami, A, Makita, Z, Yang, Z, Vlassara, H, Sehajpal, P, Horii, Y	J Exp Med	1991