Bcl-2 and Bcl-XL bind NLRP1

Stable Identifier
R-HSA-879201
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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Bcl-2 and Bcl-XL bind NLRP1
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The anti-apoptotic proteins Bcl-2 and Bcl-XL (but not Mcl-1, Bcl-W, Bfl-1 or Bcl-B) bind to NLRP1, preventing MDP-induced activation.
Literature References
PubMed ID Title Journal Year
17418785 Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

Bruey, JM, Bruey-Sedano, N, Luciano, F, Zhai, D, Balpai, R, Xu, C, Kress, CL, Bailly-Maitre, B, Li, X, Osterman, A, Matsuzawa, S, Terskikh, AV, Faustin, B, Reed, JC

Cell 2007
Participants
Input
Output
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as an event of
Orthologous Events
Bcl-2 and Bcl-XL bind NLRP1 (Bos taurus)
Bcl-2 and Bcl-XL bind NLRP1 (Canis familiaris)
Bcl-2 and Bcl-XL bind NLRP1 (Danio rerio)
Bcl-2 and Bcl-XL bind NLRP1 (Gallus gallus)
Bcl-2 and Bcl-XL bind NLRP1 (Mus musculus)
Bcl-2 and Bcl-XL bind NLRP1 (Rattus norvegicus)
Authored
Jupe, S  (2010-04-22)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2010-06-15)
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