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MEFV [cytosol]
Stable Identifier
R-HSA-877355
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Pyrin, MEFV_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
PSTPIP1 binds Pyrin (Homo sapiens)
PSTPIP1 trimer:Pyrin trimer [cytosol] (Homo sapiens)
Pyrin trimer [cytosol] (Homo sapiens)
MEFV [cytosol] (Homo sapiens)
Pyrin trimer [cytosol] (Homo sapiens)
MEFV [cytosol] (Homo sapiens)
Pyrin binds ASC (Homo sapiens)
Pyrin trimer [cytosol] (Homo sapiens)
MEFV [cytosol] (Homo sapiens)
Pyrin trimer:ASC [cytosol] (Homo sapiens)
Pyrin trimer [cytosol] (Homo sapiens)
MEFV [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
PSTPIP1 binds Pyrin (Homo sapiens)
PSTPIP1 trimer:Pyrin trimer [cytosol] (Homo sapiens)
Pyrin trimer [cytosol] (Homo sapiens)
MEFV [cytosol] (Homo sapiens)
Pyrin trimer [cytosol] (Homo sapiens)
MEFV [cytosol] (Homo sapiens)
Pyrin binds ASC (Homo sapiens)
Pyrin trimer [cytosol] (Homo sapiens)
MEFV [cytosol] (Homo sapiens)
Pyrin trimer:ASC [cytosol] (Homo sapiens)
Pyrin trimer [cytosol] (Homo sapiens)
MEFV [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15553 MEFV
Gene Names
MEFV, MEF, TRIM20
Chain
chain:1-781
Reference Genes
BioGPS Gene:4210 MEFV
COSMIC (genes):MEFV MEFV
CTD Gene:4210 MEFV
dbSNP Gene:4210 MEFV
ENSEMBL:ENSG00000103313 MEFV
HGNC:6998 MEFV
KEGG:hsa:4210 MEFV
Monarch:4210 MEFV
NCBI Gene:4210 MEFV
OMIM:608107 MEFV
UCSC:O15553 MEFV
Reference Transcript
RefSeq:NM_001198536.1 MEFV
RefSeq:NM_000243.2 MEFV
Other Identifiers
11737514_a_at
11737515_at
11752332_x_at
16823309
208262_3p_x_at
208262_x_at
3677517
3677518
3677520
3677521
3677522
3677523
3677524
3677525
3677526
3677527
3677528
3677529
3677530
3677531
3677532
3677533
3677534
4210
7998940
A_23_P140967
GE54149
GO:0001726
GO:0002221
GO:0002376
GO:0003779
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005773
GO:0005776
GO:0005829
GO:0005856
GO:0005874
GO:0005875
GO:0006954
GO:0008092
GO:0008270
GO:0010468
GO:0010508
GO:0012501
GO:0016567
GO:0016740
GO:0030027
GO:0031410
GO:0032651
GO:0032691
GO:0032695
GO:0032731
GO:0034341
GO:0042802
GO:0042995
GO:0043226
GO:0045087
GO:0046872
GO:0050728
GO:0050729
GO:0061630
GO:0061702
GO:0065003
GO:0070269
GO:0071641
GO:0098542
GO:0140096
GO:1900016
GO:1900226
GO:1904270
GO:2001056
HMNXSV003014880
ILMN_1804738
PH_hs_0010414
TC16000812.hg
Participates
as a component of
Pyrin trimer [cytosol] (Homo sapiens)
Inferred To
MEFV [cytosol]
(Bos taurus)
MEFV [cytosol]
(Caenorhabditis elegans)
MEFV [cytosol]
(Canis familiaris)
MEFV [cytosol]
(Danio rerio)
MEFV [cytosol]
(Gallus gallus)
MEFV [cytosol]
(Mus musculus)
MEFV [cytosol]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000541159
,
ENSG00000103313
,
ENSP00000219596
,
ENSP00000445079
,
ENST00000219596
,
ENST00000536379
,
ENSP00000438711
OpenTargets
ENSG00000103313
GeneCards
MEFV
HPA
ENSG00000103313-MEFV
PRO
O15553
Pharos - Targets
O15553
GlyGen
O15553
Orphanet
MEFV
PDB
8C28
,
8C30
,
2WL1
,
4CG4
,
2MPC
,
8SDJ
,
8C2Y
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
0.796
10
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