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IFNA8 [extracellular region]
Stable Identifier
R-HSA-877336
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interferon alpha-8, IFNA8_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
Evasion by RSV of host interferon responses (Homo sapiens)
Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Expression of Interferon-alpha and beta (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Activation of JAK kinases (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Formation of p-STAT1 homodimer (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFN alpha/beta binds to IFNAR2 (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Phosphorylation of INFAR1 by TYK2 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Phosphorylation of STAT2 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Recruitment of IFNAR1 (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Regulation of IFNA/IFNB signaling (Homo sapiens)
Dephosphorylation of JAK1 by SHP1 (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Dephosphorylation of STAT1 by SHP2 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Dephosphorylation of TYK2 by PTP1B (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Inhibition of JAK kinase activity by SOCS1/3 (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Release of p-STAT2:p-STAT1 dimer (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA8 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32881 IFNA8
Gene Names
IFNA8
Chain
signal peptide:1-23, chain:24-189
Reference Genes
BioGPS Gene:3445 IFNA8
COSMIC (genes):IFNA8 IFNA8
CTD Gene:3445 IFNA8
dbSNP Gene:3445 IFNA8
ENSEMBL:ENSG00000120242 IFNA8
ENSEMBL_homo_sapiens_GENE:ENSG00000120242.4 IFNA8
HGNC:5429 IFNA8
KEGG Gene (Homo sapiens):3445 IFNA8
Monarch:3445 IFNA8
NCBI Gene:3445 IFNA8
OMIM:147568 IFNA8
UCSC:P32881 IFNA8
Reference Transcript
RefSeq:NM_002170.3 IFNA8
Other Identifiers
11738431_at
17083968
207932_PM_at
207932_at
3164810
3164811
3164812
3164813
3164814
3164815
3201202
3445
8154622
A_14_P109107
A_23_P146539
GE562688
GO:0002250
GO:0002286
GO:0002323
GO:0002376
GO:0005125
GO:0005126
GO:0005132
GO:0005515
GO:0005576
GO:0005615
GO:0006952
GO:0006959
GO:0007165
GO:0019221
GO:0023052
GO:0030154
GO:0030183
GO:0033141
GO:0036211
GO:0042100
GO:0043330
GO:0048018
GO:0048856
GO:0051607
GO:0060337
GO:0098542
GO:0098586
GO:0098772
HMNXSV003030532
ILMN_2110561
PH_hs_0031302
TC09000102.hg
g10800141_3p_s_at
g184598_3p_s_at
g186407_3p_s_at
g4504598_3p_at
g4504598_3p_x_at
Participates
as a member of
IFNA [extracellular region] (Homo sapiens)
Inferred To
Homologues of IFNA1 [extracellular region]
(Bos taurus)
Homologues of IFNA1 [extracellular region]
(Canis familiaris)
Homologues of IFNA1 [extracellular region]
(Danio rerio)
Homologues of IFNA1 [extracellular region]
(Gallus gallus)
Homologues of IFNA1 [extracellular region]
(Mus musculus)
Homologues of IFNA1 [extracellular region]
(Rattus norvegicus)
Homologues of IFNA1 [extracellular region]
(Sus scrofa)
IFNAC [extracellular region]
(Bos taurus)
Ifna12 [extracellular region]
(Mus musculus)
Ifna16 [extracellular region]
(Mus musculus)
LOC120103161 [extracellular region]
(Rattus norvegicus)
LOC100911527 [extracellular region]
(Rattus norvegicus)
IFN-alpha-17 [extracellular region]
(Sus scrofa)
Ifna7 [extracellular region]
(Mus musculus)
LOC120103159 [extracellular region]
(Rattus norvegicus)
IFNA1 [extracellular region]
(Canis familiaris)
IFNA1 [extracellular region]
(Gallus gallus)
IFNA1 [extracellular region]
(Sus scrofa)
IFNA [extracellular region]
(Gallus gallus)
IFN-alpha-13 [extracellular region]
(Sus scrofa)
LOC523244 [extracellular region]
(Bos taurus)
IFN-alpha-9 [extracellular region]
(Sus scrofa)
IFN-alpha-11 [extracellular region]
(Sus scrofa)
Ifnab [extracellular region]
(Mus musculus)
Ifna13 [extracellular region]
(Mus musculus)
Ifna9 [extracellular region]
(Mus musculus)
RGD1560539 [extracellular region]
(Rattus norvegicus)
LOC100335490 [extracellular region]
(Bos taurus)
Ifna2 [extracellular region]
(Mus musculus)
ENSRNOG00000065554 [extracellular region]
(Rattus norvegicus)
LOC120103160 [extracellular region]
(Rattus norvegicus)
IFNA2 [extracellular region]
(Gallus gallus)
Ifna6 [extracellular region]
(Mus musculus)
LOC100737904 [extracellular region]
(Sus scrofa)
IFN-ALPHA-1 [extracellular region]
(Sus scrofa)
Ifna14 [extracellular region]
(Mus musculus)
IFN-alpha-4 [extracellular region]
(Sus scrofa)
LOC618947 [extracellular region]
(Bos taurus)
ifn3 [extracellular region]
(Danio rerio)
Ifna1 [extracellular region]
(Mus musculus)
Ifna1 [extracellular region]
(Rattus norvegicus)
LOC611406 [extracellular region]
(Canis familiaris)
IFN-ALPHA-10 [extracellular region]
(Sus scrofa)
Ifna5 [extracellular region]
(Mus musculus)
IFN-alpha-1 [extracellular region]
(Sus scrofa)
IFNF4 [extracellular region]
(Danio rerio)
Ifna15 [extracellular region]
(Mus musculus)
ifn [extracellular region]
(Danio rerio)
IFNAD [extracellular region]
(Bos taurus)
ifn-a [extracellular region]
(Canis familiaris)
Ifna11 [extracellular region]
(Mus musculus)
Ifna4 [extracellular region]
(Mus musculus)
Ifna4 [extracellular region]
(Rattus norvegicus)
ifn2 [extracellular region]
(Danio rerio)
LOC119876809 [extracellular region]
(Canis familiaris)
LOC120103158 [extracellular region]
(Rattus norvegicus)
LOC120103162 [extracellular region]
(Rattus norvegicus)
LOC100683567 [extracellular region]
(Canis familiaris)
CaIFN-alpha 7 [extracellular region]
(Canis familiaris)
LOC100683045 [extracellular region]
(Canis familiaris)
IFNB [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_002161.2
OpenTargets
ENSG00000120242
GeneCards
P32881
HPA
ENSG00000120242-IFNA8
Ensembl
ENSP00000369553
,
ENSG00000120242
,
ENST00000380205
PRO
P32881
Pharos - Targets
P32881
PDB
6JHD
HMDB Protein
HMDBP14009
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