Reactome | IFNAR1 [plasma membrane]

IFNAR1 [plasma membrane]

Stable Identifier

R-HSA-877334

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interferon alpha/beta receptor 1, INAR1_HUMAN

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External Reference Information

External Reference

UniProt:P17181 IFNAR1

Gene Names

IFNAR1, IFNAR

Chain

signal peptide:1-27, chain:28-557

Reference Genes

BioGPS Gene:3454 IFNAR1

COSMIC (genes):IFNAR1 IFNAR1

CTD Gene:3454 IFNAR1

dbSNP Gene:3454 IFNAR1

ENSEMBL:ENSG00000142166 IFNAR1

HGNC:5432 IFNAR1

KEGG:hsa:3454 IFNAR1

Monarch:3454 IFNAR1

NCBI Gene:3454 IFNAR1

OMIM:107450 IFNAR1

UCSC:P17181 IFNAR1

Reference Transcript

Participates

as a component of

Other forms of this molecule

p-Y466,Y481-IFNAR1 [plasma membrane]

Inferred To

ifngr2 [plasma membrane] (Xenopus tropicalis)

ifngr2.2 [plasma membrane] (Xenopus tropicalis)

il10rb [plasma membrane] (Xenopus tropicalis)

Ifnar1 [plasma membrane] (Mus musculus)

Ifnar1 [plasma membrane] (Rattus norvegicus)

Homologues of IFNAR1 [plasma membrane] (Xenopus tropicalis)

IFNAR1 [plasma membrane] (Bos taurus)

IFNAR1 [plasma membrane] (Canis familiaris)

IFNAR1 [plasma membrane] (Gallus gallus)

IFNAR1 [plasma membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

1723

ENSEMBL

ENST00000652450, ENSP00000514785, ENSP00000515348, ENST00000703556, ENST00000700080, ENST00000703515, ENSP00000515372, ENSP00000270139, ENSP00000498654, ENSG00000142166, ENST00000270139

OpenTargets

ENSG00000142166

GeneCards

IFNAR1

HPA

ENSG00000142166-IFNAR1

ZINC - Substances

INAR1_HUMAN

ZINC target

P17181

PRO

P17181

Pharos - Targets

P17181

ZINC - Predictions - Purchasable

INAR1_HUMAN

PDB

3S98, 3SE3, 4PO6, 3SE4

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.758	5
UniProt:P29597 TYK2	5	p-Y1054-TYK2 [cytosol] (R-HSA-1112598) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) TYK2 [cytosol] (R-HSA-877348) p-Y-TYK2 [cytosol] (R-HSA-6784366) p-TYK2 [cytosol] (R-HSA-8950424)	0.564	2
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.499	2