Reactome | PIAS1 [nucleoplasm]

PIAS1 [nucleoplasm]

Stable Identifier

R-HSA-877307

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 SUMO-protein ligase PIAS1, PIAS1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P29474 NOS3

Expand all

External Reference Information

External Reference

UniProt:O75925 PIAS1

Gene Names

PIAS1, DDXBP1

Chain

initiator methionine:, chain:2-651

Reference Genes

BioGPS Gene:8554 PIAS1

COSMIC (genes):PIAS1 PIAS1

CTD Gene:8554 PIAS1

dbSNP Gene:8554 PIAS1

ENSEMBL:ENSG00000033800 PIAS1

ENSEMBL_homo_sapiens_GENE:ENSG00000033800.14 PIAS1

HGNC:2752 PIAS1

KEGG Gene (Homo sapiens):8554 PIAS1

Monarch:8554 PIAS1

NCBI Gene:8554 PIAS1

OMIM:603566 PIAS1

UCSC:O75925 PIAS1

Reference Transcript

Other Identifiers

11737768_a_at

16802389

216143_PM_at

216143_at

217862_PM_at

217862_at

217863_PM_at

217863_at

217864_PM_s_at

217864_s_at

242278_PM_at

242278_at

3599330

3599331

3599333

3599341

3599366

3599367

3599370

3599372

3599376

3599384

3599388

3599389

3599390

3599392

3599393

3599395

3599400

3599401

3599402

3599403

3599404

3599405

3599406

3599407

3599408

3599409

3599410

3599411

3599412

36573_at

46559_at

55478_at

58682_at

7984453

8554

A_14_P115397

A_23_P163347

A_23_P163353

A_32_P142195

GE58693

GO:0000082

GO:0000122

GO:0000278

GO:0000976

GO:0003677

GO:0003712

GO:0003714

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005856

GO:0006351

GO:0006355

GO:0006357

GO:0007259

GO:0007283

GO:0008270

GO:0008542

GO:0012501

GO:0016605

GO:0016607

GO:0016740

GO:0016925

GO:0019789

GO:0019899

GO:0019904

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0031625

GO:0032436

GO:0033235

GO:0034399

GO:0036211

GO:0042127

GO:0043066

GO:0043226

GO:0045444

GO:0045893

GO:0046872

GO:0048856

GO:0050877

GO:0051152

GO:0060255

GO:0061665

GO:0065003

GO:0065004

GO:0140096

GO:0140110

GO:0140297

GO:1904377

HMNXSV003054447

HMNXSV003057695

Hs.250861.0.A1_3p_at

Hs.306457.0.A1_3p_at

Hs.75251.0.S2_3p_at

Hs.75251.0.S3_3p_at

ILMN_1780598

PH_hs_0004297

PH_hs_0031316

TC15000627.hg

U78524_at

g7706636_3p_a_at

Participates

as a member of

as a candidate of

PIAS1,3 [nucleoplasm] (Homo sapiens)

as a component of

p-STAT1 dimer:PIAS:SUMO1 [nucleoplasm] (Homo sapiens)

as an input of

PIAS1 binds p-STAT1 dimer (Homo sapiens)

Inferred To

PIAS1 [nucleoplasm] (Bos taurus)

PIAS1 [nucleoplasm] (Caenorhabditis elegans)

PIAS1 [nucleoplasm] (Canis familiaris)

PIAS1 [nucleoplasm] (Gallus gallus)

PIAS1 [nucleoplasm] (Saccharomyces cerevisiae)

PIAS1 [nucleoplasm] (Schizosaccharomyces pombe)

PIAS1 [nucleoplasm] (Sus scrofa)

Pias1 [nucleoplasm] (Mus musculus)

Pias1 [nucleoplasm] (Rattus norvegicus)

Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)

Homologues of PIAS1 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_016878177.1, NP_057250.1, NP_001307616.1

OpenTargets

ENSG00000033800

GeneCards

O75925

HPA

ENSG00000033800-PIAS1

Ensembl

ENSP00000249636, ENSP00000438574, ENSG00000033800, ENST00000545237, ENST00000249636

PRO

O75925

Pharos - Targets

O75925

PDB

1V66

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	19
UniProt:P54253 ATX1			0.666	7
UniProt:Q9UIS9 MBD1	2	monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331) MBD1 [nucleoplasm] (R-HSA-417134)	0.581	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.571	4
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P51608 MECP2			0.556	3
UniProt:Q9P1N4 Q9P1N4			0.556	3
UniProt:Q9NUW8 TDP1	1	TDP1 [nucleoplasm] (R-HSA-175593)	0.556	3
UniProt:O43933 PEX1	1	PEX1 [cytosol] (R-HSA-9033116)	0.556	3
UniProt:P01023 A2M	2	A2M [extracellular region] (R-HSA-49291) A2M [platelet alpha granule lumen] (R-HSA-139834)	0.556	3
UniProt:P35240-4 NF2			0.556	3
UniProt:A0A0S2Z5Q7 A0A0S2Z5Q7			0.556	3
UniProt:P07686 HEXB	11	HEXB S62L [lysosomal lumen] (R-HSA-3700901) HEXB R284* [lysosomal lumen] (R-HSA-3700930) HEXB M26Cfs5 [lysosomal lumen] (R-HSA-3700843) HEXB I322Kfs5 [lysosomal lumen] (R-HSA-3700889) HEXB(315-556) [extracellular region] (R-HSA-6806188) HEXB(122-311) [extracellular region] (R-HSA-6806190) HEXB(315-556) [azurophil granule lumen] (R-HSA-6799134) HEXB(122-311) [azurophil granule lumen] (R-HSA-6799125) HEXB(316-556) [lysosomal lumen] (R-HSA-1605605) HEXB(122-311) [lysosomal lumen] (R-HSA-1605777) HEXB(50-107) [lysosomal lumen] (R-HSA-9842398)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P45381 ASPA	1	ASPA [cytosol] (R-HSA-5691513)	0.556	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.556	3
UniProt:P26378-2 P263782			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P41219 PERI			0.556	3
UniProt:Q9UBB4 ATX10			0.556	3
UniProt:P54577 YARS1	1	YARS [cytosol] (R-HSA-379560)	0.556	3
UniProt:Q6NUL7 Q6NUL7			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	9
UniProt:P05129 PRKCG	1	PRKCG [cytosol] (R-HSA-58204)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:Q13216-2 ERCC8			0.556	3
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:P28358 HXD10			0.556	3
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:O00628 PEX7	2	PEX7 [peroxisomal membrane] (R-HSA-9033493) PEX7 [cytosol] (R-HSA-9033107)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:P29474 NOS3	9	2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane] (R-HSA-9860783) 2xPalmC-MyrG-p-S633-NOS3 [plasma membrane] (R-HSA-9861341) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) MyrG-NOS3 [cytosol] (R-HSA-203687) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) NOS3 [cytosol] (R-HSA-202114)	0.556	3
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.556	3
UniProt:O14832 PHYH	4	PHYH [peroxisomal matrix] (R-HSA-389574) PHYH(1-338) [cytosol] (R-HSA-9033143) PHYH(1-338) [peroxisomal matrix] (R-HSA-9033535) PHYH(1-30) [peroxisomal matrix] (R-HSA-9033518)	0.556	3
UniProt:Q16595 FXN	6	FXN(42-210) [mitochondrial matrix] (R-HSA-1299445) FXN(1-210) [mitochondrial intermembrane space] (R-HSA-1299451) FXN(81-210) [mitochondrial matrix] (R-HSA-1362390) FXN(1-41) [mitochondrial matrix] (R-HSA-8986117) FXN(1-210) [mitochondrial inner membrane] (R-HSA-1299444) FXN(42-210) [mitochondrial inner membrane] (R-HSA-1299454)	0.556	3
UniProt:P50897 PPT1	1	PPT1 [lysosomal lumen] (R-HSA-5690068)	0.556	3
UniProt:Q16143 SNCB	1	SNCB [cytosol] (R-HSA-5660390)	0.556	3
UniProt:P02545-2 LMNA	5	LMNA-2 [nuclear envelope] (R-HSA-912378) p-S22, S395-LMNA-2 [nucleoplasm] (R-HSA-5229019) p-S395-LMNA-2 [nucleoplasm] (R-HSA-5228740) Lamin C [nucleoplasm] (R-HSA-264872) LMNA-2 [cytosol] (R-HSA-2995387)	0.556	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.553	2
UniProt:O75626 PRDM1	1	PRDM1 [nucleoplasm] (R-HSA-6804199)	0.524	2
UniProt:P11308 ERG			0.519	2
UniProt:Q9UKL3 CASP8AP2	2	monoSUMO1-K1813-CASP8AP2 [nucleoplasm] (R-HSA-3927850) CASP8AP2 [nucleoplasm] (R-HSA-3927945)	0.508	4
UniProt:G2XKQ0 SUMO5			0.488	2
UniProt:P03118 VE2			0.488	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2

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