Reactome | PIAS1 binds p-STAT1 dimer

PIAS1 binds p-STAT1 dimer

Stable Identifier

R-HSA-877281

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

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PIAS1 protein interacts directly with phoshorylated STAT1 dimers and inhibit the transcriptional activity of STAT1 by blocking the DNA-binding domain of STAT1. It has also been suggested that PIAS proteins might regulate transcription by promoting small ubiquitin-related modifier (SUMO1) conjugation of STAT1. The significance of STAT1 sumoylation in regulating STAT1 activity is controversial and needs to be clarified.

Literature References

PubMed ID	Title	Journal	Year
18031232	PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription Palvimo, JJ	Biochem Soc Trans	2007
10805787	Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction Liao, J, Fu, Y, Shuai, K	Proc Natl Acad Sci U S A	2000
12855578	PIAS proteins promote SUMO-1 conjugation to STAT1 Palvimo, JJ, Vanhatupa, S, Aittomaki, S, Ungureanu, D, Silvennoinen, O, Yang, J, Jänne, OA, Kotaja, N	Blood	2003