PIAS1 protein interacts directly with phoshorylated STAT1 dimers and inhibit the transcriptional activity of STAT1 by blocking the DNA-binding domain of STAT1. It has also been suggested that PIAS proteins might regulate transcription by promoting small ubiquitin-related modifier (SUMO1) conjugation of STAT1. The significance of STAT1 sumoylation in regulating STAT1 activity is controversial and needs to be clarified.
Liao, J, Fu, Y, Shuai, K
Palvimo, JJ
Ungureanu, D, Vanhatupa, S, Kotaja, N, Yang, J, Aittomaki, S, Jänne, OA, Palvimo, JJ, Silvennoinen, O
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