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P2RX7 [plasma membrane]
Stable Identifier
R-HSA-877215
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
P2X7, P2X purinoceptor 7, P2RX7_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes (Homo sapiens)
ATP binds P2RX7 in P2RX7 trimer:PANX1 heptamer (Homo sapiens)
ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane] (Homo sapiens)
ATP:P2X7 oligomer [plasma membrane] (Homo sapiens)
ATP:P2X7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2RX7 trimer:PANX1 heptamer [plasma membrane] (Homo sapiens)
P2RX7 trimer [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol (Homo sapiens)
ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane] (Homo sapiens)
ATP:P2X7 oligomer [plasma membrane] (Homo sapiens)
ATP:P2X7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2RX7 trimer [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region (Homo sapiens)
P2RX7:PANX1,ATP:P2RX7:PANX1 [plasma membrane] (Homo sapiens)
ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane] (Homo sapiens)
ATP:P2X7 oligomer [plasma membrane] (Homo sapiens)
ATP:P2X7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2RX7 trimer:PANX1 heptamer [plasma membrane] (Homo sapiens)
P2RX7 trimer [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
ATP binds P2RX4,7 (Homo sapiens)
ATP:P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2RX4,7 binds itself to form trimeric non-selective cation channels (Homo sapiens)
ATP:P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
ATP:P2X4,7 trimer [plasma membrane] (Homo sapiens)
ATP:P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX4,7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Binding of ATP to P2X receptors (Homo sapiens)
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2X purinoreceptors:ATP [plasma membrane] (Homo sapiens)
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
P2X1-mediated entry of Ca++ from plasma (Homo sapiens)
P2X purinoreceptors:ATP [plasma membrane] (Homo sapiens)
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
ATP binds to P2X7 (Homo sapiens)
ATP:P2X7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2X7 forms oligomeric non-selective cation channels (Homo sapiens)
ATP:P2X7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
ATP:P2X7 oligomer [plasma membrane] (Homo sapiens)
ATP:P2X7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2X7 mediates loss of intracellular K+ (Homo sapiens)
ATP:P2X7 oligomer [plasma membrane] (Homo sapiens)
ATP:P2X7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
P2X7 mediates membrane pores that include pannexin-1 (Homo sapiens)
ATP:P2X7 oligomer [plasma membrane] (Homo sapiens)
ATP:P2X7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane] (Homo sapiens)
ATP:P2X7 oligomer [plasma membrane] (Homo sapiens)
ATP:P2X7 [plasma membrane] (Homo sapiens)
P2RX7 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99572 P2RX7
Gene Names
P2RX7
Chain
chain:1-595
Reference Genes
BioGPS Gene:5027 P2RX7
COSMIC (genes):P2RX7 P2RX7
CTD Gene:5027 P2RX7
dbSNP Gene:5027 P2RX7
ENSEMBL:ENSG00000089041 P2RX7
HGNC:8537 P2RX7
KEGG:hsa:5027 P2RX7
Monarch:5027 P2RX7
NCBI Gene:5027 P2RX7
OMIM:602566 P2RX7
UCSC:Q99572 P2RX7
Reference Transcript
RefSeq:XM_011538420.2 P2RX7
RefSeq:NM_002562.5 P2RX7
Other Identifiers
11736064_x_at
11736065_x_at
11747607_a_at
11747608_a_at
11747609_x_at
11748483_a_at
16758052
16758072
207091_PM_at
207091_at
230741_PM_at
230741_at
3091987
33697_at
3434727
3434728
3434731
3434733
3434734
3434735
3434736
3434739
3434741
3434742
3434743
3434744
3434745
3434746
3434747
3434749
3434750
3434752
3434753
3434755
3434757
3471107
5027
51015_at
7959251
A_14_P118381
A_21_P0007504
A_23_P25354
A_32_P30004
A_33_P3263867
GE61642
GE84992
GO:0000165
GO:0000902
GO:0001530
GO:0001614
GO:0001845
GO:0001913
GO:0001916
GO:0002028
GO:0002376
GO:0002931
GO:0004931
GO:0005102
GO:0005215
GO:0005216
GO:0005515
GO:0005524
GO:0005737
GO:0005739
GO:0005886
GO:0005911
GO:0006509
GO:0006629
GO:0006649
GO:0006811
GO:0006812
GO:0006816
GO:0006884
GO:0006900
GO:0006954
GO:0007005
GO:0007009
GO:0007040
GO:0007165
GO:0007166
GO:0008289
GO:0009306
GO:0009410
GO:0009612
GO:0009617
GO:0009897
GO:0010043
GO:0010467
GO:0010524
GO:0010628
GO:0012501
GO:0014047
GO:0014049
GO:0014051
GO:0014054
GO:0014070
GO:0015267
GO:0016020
GO:0016079
GO:0016192
GO:0016485
GO:0017121
GO:0019233
GO:0019722
GO:0030163
GO:0030501
GO:0031594
GO:0032059
GO:0032060
GO:0032308
GO:0032310
GO:0032496
GO:0032730
GO:0032731
GO:0032755
GO:0032963
GO:0033198
GO:0034220
GO:0034405
GO:0034767
GO:0035590
GO:0038023
GO:0042098
GO:0042802
GO:0043025
GO:0043029
GO:0043065
GO:0043132
GO:0043226
GO:0043409
GO:0043410
GO:0045202
GO:0045332
GO:0045778
GO:0045779
GO:0045794
GO:0045821
GO:0046513
GO:0046931
GO:0048705
GO:0048873
GO:0050714
GO:0050830
GO:0050877
GO:0051209
GO:0051495
GO:0051592
GO:0051602
GO:0051604
GO:0051649
GO:0051882
GO:0051899
GO:0051901
GO:0055085
GO:0060079
GO:0060089
GO:0060907
GO:0061024
GO:0065003
GO:0070227
GO:0070230
GO:0070231
GO:0070234
GO:0070588
GO:0071318
GO:0071359
GO:0071407
GO:0072593
GO:0097190
GO:0097191
GO:0098542
GO:0098655
GO:0098793
GO:0098794
GO:1904172
HMNXSV003023814
HMNXSV003028163
Hs.41322.0.A1_3p_at
ILMN_1759326
PH_hs_0018915
PH_hs_0022228
TC12000955.hg
TC12002617.hg
TC12002618.hg
Y09561_at
g4505552_3p_at
p18944
p3887
Participates
as a member of
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX4,7 [plasma membrane] (Homo sapiens)
as a component of
P2RX7 trimer [plasma membrane] (Homo sapiens)
ATP:P2X7 [plasma membrane] (Homo sapiens)
as an input of
ATP binds to P2X7 (Homo sapiens)
Inferred To
p2xC [plasma membrane]
(Dictyostelium discoideum)
p2rx7 [plasma membrane]
(Danio rerio)
P2rx7 [plasma membrane]
(Mus musculus)
P2rx7 [plasma membrane]
(Rattus norvegicus)
Homologues of P2RX7 [plasma membrane]
(Dictyostelium discoideum)
p2xB [plasma membrane]
(Dictyostelium discoideum)
p2xD [plasma membrane]
(Dictyostelium discoideum)
p2xA [plasma membrane]
(Dictyostelium discoideum)
P2RX7 [plasma membrane]
(Bos taurus)
P2RX7 [plasma membrane]
(Canis familiaris)
P2RX7 [plasma membrane]
(Gallus gallus)
P2RX7 [plasma membrane]
(Sus scrofa)
p2xE [plasma membrane]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_002553.3
,
XP_011536722.1
ZINC - Investigational
P2RX7_HUMAN
Guide to Pharmacology - Targets
484
ENSEMBL
ENST00000535250
,
ENST00000535600
,
ENSP00000442572
,
ENSP00000441230
,
ENSP00000330696
,
ENST00000328963
,
ENST00000541022
,
ENSP00000442470
,
ENSP00000437729
,
ENST00000541716
OpenTargets
ENSG00000089041
HPA
ENSG00000089041-P2RX7
ZINC - Substances
P2RX7_HUMAN
ZINC target
Q99572
PRO
Q99572
Pharos - Targets
Q99572
Orphanet
P2RX7
ZINC - Predictions - Purchasable
P2RX7_HUMAN
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.718
6
UniProt:O95967 EFEMP2
1
EFEMP2 [extracellular region]
(R-HSA-2161231)
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
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