Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
AIM2 [cytosol]
Stable Identifier
R-HSA-874111
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Interferon-inducible protein AIM2, AIM2_HUMAN, Absent in melanoma 2
Locations in the PathwayBrowser for interactor UniProt:Q9ULZ3 PYCARD
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
AIM2 binds dsDNA (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The AIM2 inflammasome (Homo sapiens)
AIM2 binds dsDNA (Homo sapiens)
AIM2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14862 AIM2
Gene Names
AIM2
Chain
chain:1-343
Reference Genes
BioGPS Gene:9447 AIM2
COSMIC (genes):AIM2 AIM2
CTD Gene:9447 AIM2
dbSNP Gene:9447 AIM2
ENSEMBL:ENSG00000163568 AIM2
ENSEMBL_homo_sapiens_GENE:ENSG00000163568.16 AIM2
HGNC:357 AIM2
KEGG Gene (Homo sapiens):9447 AIM2
Monarch:9447 AIM2
NCBI Gene:9447 AIM2
OMIM:604578 AIM2
UCSC:O14862 AIM2
Reference Transcript
RefSeq:XM_017002848.1 AIM2
RefSeq:NM_004833.2 AIM2
Other Identifiers
11730457_a_at
11730458_at
16695121
206513_PM_at
206513_at
2439555
2439556
2439559
2439561
2439562
2439563
2439565
2439566
2439567
2439568
2439569
2439571
2439587
2439588
2439589
2439598
31603_at
34439_at
7921434
9447
A_32_P44394
GE54190
GO:0002218
GO:0002221
GO:0002230
GO:0002376
GO:0003677
GO:0003690
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006351
GO:0006355
GO:0006954
GO:0006955
GO:0006974
GO:0007420
GO:0012501
GO:0023052
GO:0032088
GO:0032731
GO:0033209
GO:0035458
GO:0035591
GO:0035861
GO:0038187
GO:0042802
GO:0043029
GO:0043226
GO:0045087
GO:0048856
GO:0050729
GO:0050795
GO:0051092
GO:0051607
GO:0051898
GO:0060089
GO:0060090
GO:0061702
GO:0065003
GO:0070050
GO:0070269
GO:0071466
GO:0097169
GO:0098542
GO:0098772
GO:0140608
GO:0140970
GO:1904270
GO:2001056
HMNXSV003010367
HMNXSV003041218
ILMN_1681301
ILMN_2214232
PH_hs_0005844
TC01003383.hg
g4757733_3p_at
Participates
as an input of
AIM2 binds dsDNA (Homo sapiens)
as a component of
dsDNA:AIM2 [cytosol] (Homo sapiens)
Inferred To
Aim2 [cytosol]
(Mus musculus)
Aim2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_004824.1
,
XP_016858337.1
Guide to Pharmacology - Targets
2923
OpenTargets
ENSG00000163568
GeneCards
O14862
HPA
ENSG00000163568-AIM2
Ensembl
ENST00000411768
,
ENST00000368130
,
ENSP00000512039
,
ENSP00000512040
,
ENSP00000357112
,
ENSG00000163568
,
ENST00000695580
PRO
O14862
Pharos - Targets
O14862
PDB
3RN2
,
6MB2
,
3RN5
,
3VD8
,
4O7Q
,
7K3R
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
0.892
13
UniProt:O14862 AIM2
1
AIM2 [cytosol]
(R-HSA-874111)
0.656
3
UniProt:P29466 CASP1
5
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(1-404) [cytosol]
(R-HSA-448692)
0.488
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text