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GNRH2(24-33) [extracellular region]
Stable Identifier
R-HSA-873940
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
GNRH2, Progonadoliberin-2, GON2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Hormone ligand-binding receptors (Homo sapiens)
GNRHR binds GNRH1,2 (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
GNRHR2 binds GNRH1,2 (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH2(24-33) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43555 GNRH2
Gene Names
GNRH2
Chain
signal peptide:1-23, chain:24-120, peptide:24-33, peptide:37-120
Reference Genes
BioGPS Gene:2797 GNRH2
COSMIC (genes):GNRH2 GNRH2
CTD Gene:2797 GNRH2
dbSNP Gene:2797 GNRH2
ENSEMBL:ENSG00000125787 GNRH2
ENSEMBL_homo_sapiens_GENE:ENSG00000125787.11 GNRH2
HGNC:4420 GNRH2
KEGG Gene (Homo sapiens):2797 GNRH2
Monarch:2797 GNRH2
NCBI Gene:2797 GNRH2
OMIM:602352 GNRH2
UCSC:O43555 GNRH2
Reference Transcript
RefSeq:XM_017027823.1 GNRH2
RefSeq:NM_178331.1 GNRH2
RefSeq:NM_001310220.1 GNRH2
RefSeq:NM_178332.1 GNRH2
RefSeq:NM_001501.1 GNRH2
Other Identifiers
11731329_at
16910948
208519_PM_x_at
208519_x_at
2797
31337_at
3874169
3874170
3874171
3874172
3874174
8060594
A_23_P40272
A_24_P323072
A_33_P3418790
GO:0000003
GO:0005179
GO:0005183
GO:0005576
GO:0005615
GO:0007165
GO:0007275
GO:0023052
GO:0031530
GO:0048018
GO:0048856
GO:0098772
HMNXSV003033296
HMNXSV003042252
ILMN_1697845
ILMN_2354285
PH_hs_0029166
TC20000031.hg
g4504056_3p_at
g4504056_3p_s_at
Participates
as a member of
GNRH1,2 [extracellular region] (Homo sapiens)
Inferred To
GNRH2 [extracellular region]
(Bos taurus)
GNRH2 [extracellular region]
(Sus scrofa)
cGnRH-II [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_001297149.1
,
XP_016883312.1
,
NP_847901.1
,
NP_001492.1
,
NP_847902.1
OpenTargets
ENSG00000125787
HPA
ENSG00000125787-GNRH2
GeneCards
O43555
Ensembl
ENSP00000369705
,
ENST00000380346
,
ENST00000245983
,
ENST00000359100
,
ENSP00000245983
,
ENSP00000369704
,
ENSP00000352003
,
ENSG00000125787
,
ENST00000380347
PRO
O43555
Pharos - Targets
O43555
Orphanet
24563
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