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GNRH1(24-33) [extracellular region]
Stable Identifier
R-HSA-873934
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
GNRH1, Progonadoliberin-1, GON1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Hormone ligand-binding receptors (Homo sapiens)
GNRHR binds GNRH1,2 (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
GNRHR2 binds GNRH1,2 (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
GNRHR2:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRH1,2 [extracellular region] (Homo sapiens)
GNRH1(24-33) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01148 GNRH1
Gene Names
GNRH1, GNRH, GRH, LHRH
Chain
signal peptide:1-23, chain:24-92, peptide:24-33, peptide:37-92
Reference Genes
BioGPS Gene:2796 GNRH1
COSMIC (genes):GNRH1 GNRH1
CTD Gene:2796 GNRH1
dbSNP Gene:2796 GNRH1
ENSEMBL:ENSG00000147437 GNRH1
HGNC:4419 GNRH1
KEGG:hsa:2796 GNRH1
Monarch:2796 GNRH1
NCBI Gene:2796 GNRH1
OMIM:152760 GNRH1
UCSC:P01148 GNRH1
Reference Transcript
RefSeq:NM_001083111.1 GNRH1
Other Identifiers
11728495_a_at
11728496_a_at
17075594
17075601
207987_PM_s_at
207987_s_at
235540_PM_at
235540_at
2796
3128364
3128365
3128366
3128367
3128368
3128369
3128370
36801_at
76114_at
8149849
A_23_P254594
GE80956
GO:0005179
GO:0005183
GO:0005576
GO:0005615
GO:0007165
GO:0007267
GO:0007275
GO:0010468
GO:0023052
GO:0031530
GO:0045471
GO:0048018
GO:0048545
GO:0048856
GO:0098772
GO:2000354
GO:2001223
HMNXSV003020004
HMNXSV003032891
HMNXSV003055365
Hs.115452.0.A1_3p_at
ILMN_1745991
PH_hs_0004746
TC08001069.hg
X01059_at
g4504054_3p_a_at
p15632
Participates
as a member of
GNRH1,2 [extracellular region] (Homo sapiens)
Inferred To
Gnrh1 [extracellular region]
(Mus musculus)
Gnrh1 [extracellular region]
(Rattus norvegicus)
GNRH1 [extracellular region]
(Bos taurus)
GNRH1 [extracellular region]
(Canis familiaris)
GNRH1 [extracellular region]
(Gallus gallus)
GNRH1 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001076580.1
ENSEMBL
ENST00000421054
,
ENSP00000391280
,
ENSG00000147437
,
ENST00000276414
,
ENSP00000276414
OpenTargets
ENSG00000147437
GeneCards
GNRH1
HPA
ENSG00000147437-GNRH1
PRO
P01148
Pharos - Targets
P01148
Orphanet
GNRH1
PDB
4D5M
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