Reactome | Phosphorylation of STAT1 by JAK kinases

Phosphorylation of STAT1 by JAK kinases

Stable Identifier

R-HSA-873922

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

STAT1 pair recruited to the receptor complex is phosphorylated near the C-terminus at residue Y701, probably by JAK2. This phosphorylation enables the STAT1 homodimer formation which is further phosphorylated on residue S727.

Literature References

PubMed ID	Title	Journal	Year
7690989	A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma Shuai, K, Stark, GR, Kerr, IM, Darnell JE, Jr	Science	1993
7657660	Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor Quelle, FW, Thierfelder, W, Witthuhn, BA, Tang, B, Cohen, S, Ihle, JN	J Biol Chem	1995
8631301	Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state Briscoe, J, Rogers, NC, Witthuhn, BA, Watling, D, Harpur, AG, Wilks, AF, Stark, GR, Ihle, JN, Kerr, IM	EMBO J	1996
12040185	A road map for those who don't know JAK-STAT Aaronson, DS, Horvath, CM	Science	2002