Phosphorylation of STAT1 by JAK kinases

Stable Identifier
Homo sapiens
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STAT1 pair recruited to the receptor complex is phosphorylated near the C-terminus at residue Y701, probably by JAK2. This phosphorylation enables the STAT1 homodimer formation which is further phosphorylated on residue S727.

Literature References
PubMed ID Title Journal Year
7657660 Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor

Witthuhn, BA, Thierfelder, W, Quelle, FW, Cohen, S, Tang, B, Ihle, JN

J Biol Chem 1995
7690989 A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

Stark, GR, Darnell JE, Jr, Kerr, IM, Shuai, K

Science 1993
8631301 Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state

Witthuhn, BA, Wilks, AF, Stark, GR, Watling, D, Kerr, IM, Briscoe, J, Rogers, NC, Harpur, AG, Ihle, JN

EMBO J 1996
12040185 A road map for those who don't know JAK-STAT

Horvath, CM, Aaronson, DS

Science 2002
Catalyst Activity

protein tyrosine kinase activity of STAT1 bound to p-IFNGR1 [plasma membrane]

Orthologous Events
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