STAT1 pair recruited to the receptor complex is phosphorylated near the C-terminus at residue Y701, probably by JAK2. This phosphorylation enables the STAT1 homodimer formation which is further phosphorylated on residue S727.
Shuai, K, Stark, GR, Kerr, IM, Darnell JE, Jr
Quelle, FW, Thierfelder, W, Witthuhn, BA, Tang, B, Cohen, S, Ihle, JN
Briscoe, J, Rogers, NC, Witthuhn, BA, Watling, D, Harpur, AG, Wilks, AF, Stark, GR, Ihle, JN, Kerr, IM
Aaronson, DS, Horvath, CM
protein tyrosine kinase activity of STAT1 bound to p-IFNGR1 [plasma membrane]
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