Reactome | Phosphorylation of JAK2

Phosphorylation of JAK2

Stable Identifier

R-HSA-873919

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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IFN-gamma binding to the receptor complex, induces JAK2 autophosphorylation and activation. Like all protein tyrosine kinases (PTKs) JAK2 activity also depends on the phosphorylation of tandem tyrosine residues within the activation loop that results in the removal of the activation loop from the active site. Multiple phosphorylation sites have been identified in JAK2 (tyrosines 221, 570, 868, 966, 972, 1007 and 1008 ) of which phosphorylation of tyrosine 1007 is essential for kinase activity. Tyrosine 1007 is in the activation loop and phosphorylation allows access of the catalytic loop to the ATP in the ATP binding domain. Of all the predicted phoshorylation sites only tyrosine 1007 is represented in the reaction.

Literature References

PubMed ID	Title	Journal	Year
9111318	Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop Matsuda, T, Witthuhn, BA, Kerr, IM, Kohlhuber, F, Feng, J, Ihle, JN	Mol Cell Biol	1997
15530433	Determination of the transphosphorylation sites of Jak2 kinase Witthuhn, BA, Matsuda, T, Feng, J, Ihle, JN, Sekine, Y	Biochem Biophys Res Commun	2004
15143187	Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity Steen, H, Carter-Su, C, Argetsinger, LS, Jensen, ON, Kouadio, JL, Stensballe, A	Mol Cell Biol	2004
20304997	Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity Carter-Su, C, Marto, JA, Cline, JM, Argetsinger, LS, Koleva, RI, Robertson, SA, Stuckey, JA, Myers MG, Jr	Mol Endocrinol	2010