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SOCS3 [cytosol]
Stable Identifier
R-HSA-873794
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Suppressor of cytokine signaling 3, SOCS3_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P51451 BLK
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (Homo sapiens)
SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)
SOCS3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)
p-Y-STAT1,3,5 dimer enhances expression of SOCS3 (Homo sapiens)
SOCS3 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
SOCS3 binds IL6ST (Homo sapiens)
SOCS3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Leptin (Homo sapiens)
Phosphorylated LEPR Binds SOCS3 (Homo sapiens)
SOCS3 [cytosol] (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Activates STAT3 (Homo sapiens)
SOCS3 binds activated PTK6 (Homo sapiens)
SOCS3 [cytosol] (Homo sapiens)
STAT3 stimulates SOCS3 expression (Homo sapiens)
SOCS3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14543 SOCS3
Gene Names
SOCS3, CIS3, SSI3
Chain
chain:1-225
Reference Genes
BioGPS Gene:9021 SOCS3
COSMIC (genes):SOCS3 SOCS3
CTD Gene:9021 SOCS3
dbSNP Gene:9021 SOCS3
ENSEMBL:ENSG00000184557 SOCS3
ENSEMBL_homo_sapiens_GENE:ENSG00000184557.4 SOCS3
HGNC:19391 SOCS3
KEGG Gene (Homo sapiens):9021 SOCS3
Monarch:9021 SOCS3
NCBI Gene:9021 SOCS3
OMIM:604176 SOCS3
Reference Transcript
RefSeq:NM_003955.4 SOCS3
Other Identifiers
11719217_a_at
11719218_at
16849400
206359_3p_at
206359_PM_at
206359_at
206360_PM_s_at
206360_s_at
227697_3p_at
227697_PM_at
227697_at
3772287
3772288
3772289
3772290
3772291
3772292
3772293
3772294
3772296
3772297
40968_at
42363_r_at
49140_at
8018864
9021
A_23_P207058
A_23_P351069
GE53118
GO:0001784
GO:0001932
GO:0002376
GO:0003723
GO:0004860
GO:0005515
GO:0005829
GO:0005886
GO:0005942
GO:0006629
GO:0006954
GO:0007165
GO:0009898
GO:0009968
GO:0012501
GO:0016567
GO:0023052
GO:0030154
GO:0030292
GO:0035198
GO:0035556
GO:0036211
GO:0042532
GO:0043066
GO:0045597
GO:0046426
GO:0046627
GO:0046854
GO:0046935
GO:0048856
GO:0050728
GO:0060670
GO:0060674
GO:0072540
GO:0097398
GO:0098772
GO:1990830
HMNXSV003036284
Hs.296176.0.S2_3p_s_at
Hs.311405.0.A1_3p_at
Hs.311405.0.A1_3p_s_at
Hs.311405.0.A1_3p_x_at
ILMN_1781001
ILMN_2156250
PH_hs_0025550
TC17001917.hg
g4507234_3p_a_at
Participates
as an input of
Phosphorylated LEPR Binds SOCS3 (Homo sapiens)
SOCS3 binds IL6ST (Homo sapiens)
SOCS3 binds activated PTK6 (Homo sapiens)
as a member of
STAT3-upregulated cytosolic proteins [cytosol] (Homo sapiens)
SOCS [cytosol] (Homo sapiens)
CIS, SOCS1-3 [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
SOCS-1 and SOCS-3 [cytosol] (Homo sapiens)
as an output of
p-Y-STAT1,3,5 dimer enhances expression of SOCS3 (Homo sapiens)
SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)
STAT3 stimulates SOCS3 expression (Homo sapiens)
as a component of
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
p-Y342-PTK6:SOCS3 [cytosol] (Homo sapiens)
LEP:p-LEPR:p-JAK2:SOCS3 [plasma membrane] (Homo sapiens)
Inferred To
Socs3 [cytosol]
(Mus musculus)
Socs3 [cytosol]
(Rattus norvegicus)
SOCS3 [cytosol]
(Bos taurus)
SOCS3 [cytosol]
(Canis familiaris)
SOCS3 [cytosol]
(Gallus gallus)
SOCS3 [cytosol]
(Sus scrofa)
socs3b [cytosol]
(Danio rerio)
socs3 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003946.3
OpenTargets
ENSG00000184557
GeneCards
O14543
HPA
ENSG00000184557-SOCS3
Ensembl
ENSG00000184557
,
ENST00000330871
,
ENSP00000330341
PRO
O14543
Pharos - Targets
O14543
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N8K9 K1958
0.718
6
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.718
6
UniProt:P42681 TXK
3
TXK [cytosol]
(R-HSA-3448733)
p-Y91,Y420-TXK [cytosol]
(R-HSA-3448740)
p-Y420-TXK [cytosol]
(R-HSA-3448734)
0.556
3
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.556
3
UniProt:I6L996 I6L996
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q66K74 MAP1S
0.543
6
UniProt:Q92546 RGP1
2
RGP1 [trans-Golgi network membrane]
(R-HSA-6810986)
RGP1 [cytosol]
(R-HSA-8847842)
0.527
2
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.527
3
UniProt:Q15370 ELOB
2
TCEB2 [nucleoplasm]
(R-HSA-112423)
ELOB [cytosol]
(R-HSA-180551)
0.527
3
UniProt:Q13061-3 TRDN
0.488
2
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.488
2
UniProt:P20936 RASA1
1
RASA1 [cytosol]
(R-HSA-186833)
0.462
2
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