Reactome | SOCS3 [cytosol]

SOCS3 [cytosol]

Stable Identifier

R-HSA-873794

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Suppressor of cytokine signaling 3, SOCS3_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P20936 RASA1

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (Homo sapiens)
        
        SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)
        
        SOCS3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14543 SOCS3

Gene Names

SOCS3, CIS3, SSI3

Chain

chain:1-225

Reference Genes

BioGPS Gene:9021 SOCS3

COSMIC (genes):SOCS3 SOCS3

CTD Gene:9021 SOCS3

dbSNP Gene:9021 SOCS3

ENSEMBL:ENSG00000184557 SOCS3

HGNC:19391 SOCS3

KEGG Gene (Homo sapiens):9021 SOCS3

Monarch:9021 SOCS3

NCBI Gene:9021 SOCS3

OMIM:604176 SOCS3

Reference Transcript

RefSeq:NM_003955.4 SOCS3

Other Identifiers

0003060487

11719217_a_at

11719218_at

16849400

206359_3p_at

206359_PM_at

206359_at

206360_PM_s_at

206360_s_at

227697_3p_at

227697_PM_at

227697_at

3772287

3772288

3772289

3772290

3772291

3772292

3772293

3772294

3772296

3772297

40968_at

42363_r_at

49140_at

8018864

9021

A_23_P207058

A_23_P351069

GE53118

GO:0000003

GO:0001784

GO:0001932

GO:0003674

GO:0004860

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005942

GO:0006464

GO:0006629

GO:0006950

GO:0007165

GO:0007259

GO:0008150

GO:0008219

GO:0009058

GO:0009790

GO:0009968

GO:0016567

GO:0030154

GO:0030234

GO:0032991

GO:0035556

GO:0040007

GO:0040008

GO:0042532

GO:0043066

GO:0043086

GO:0043551

GO:0045595

GO:0045597

GO:0046426

GO:0046627

GO:0046854

GO:0046935

GO:0048856

GO:0050728

GO:0060670

GO:0060674

GO:0060707

GO:0060708

GO:1990830

HMNXSV003036284

Hs.296176.0.S2_3p_s_at

Hs.311405.0.A1_3p_at

Hs.311405.0.A1_3p_s_at

Hs.311405.0.A1_3p_x_at

ILMN_1781001

ILMN_2156250

PH_hs_0025550

TC17001917.hg

g4507234_3p_a_at

Participates

as an input of

as a member of

as an output of

as a component of

Inferred To

Socs3 [cytosol] (Mus musculus)

Socs3 [cytosol] (Rattus norvegicus)

SOCS3 [cytosol] (Bos taurus)

SOCS3 [cytosol] (Gallus gallus)

SOCS3 [cytosol] (Sus scrofa)

socs3b [cytosol] (Danio rerio)

Ghost homologue of SOCS3 [cytosol] (Canis familiaris)

socs3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_003946.3

OpenTargets

ENSG00000184557

GeneCards

O14543

HPA

ENSG00000184557-SOCS3

Ensembl

ENSP00000330341, ENST00000330871, ENSG00000184557

PRO

O14543

Pharos - Targets

O14543

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.718	6
UniProt:Q8N8K9 K1958			0.718	6
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.556	3
UniProt:P42681 TXK	3	TXK [cytosol] (R-HSA-3448733) p-Y91,Y420-TXK [cytosol] (R-HSA-3448740) p-Y420-TXK [cytosol] (R-HSA-3448734)	0.556	3
UniProt:I6L996 I6L996			0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q66K74 MAP1S			0.543	6
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.488	2
UniProt:Q13061-3 TRDN			0.488	2
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.462	2

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