Reactome | TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus

TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus

Stable Identifier

R-HSA-870538

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus

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E3 ubiquitin protein ligase TRIM33 (also known as Ecto, Ectodermin or Tif1-gamma) binds to the SMAD heterotrimer, composed of SMAD4 and two phosphorylated R-SMADs (SMAD2 and/or SMAD3), in the nucleus (Dupont et al. 2009, Dupont et al. 2005, He et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
19135894	FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination Dupont, S, Mamidi, A, Cordenonsi, M, Montagner, M, Zacchigna, L, Adorno, M, Martello, G, Stinchfield, MJ, Soligo, S, Morsut, L, Inui, M, Moro, S, Modena, N, Argenton, F, Newfeld, SJ, Piccolo, S	Cell	2009
16751102	Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway He, W, Dorn, DC, Erdjument-Bromage, H, Tempst, P, Moore, MA, Massague, J	Cell	2006
15820681	Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase Dupont, S, Zacchigna, L, Cordenonsi, M, Soligo, S, Adorno, M, Rugge, M, Piccolo, S	Cell	2005