Reactome | USP9X [cytosol]

USP9X [cytosol]

Stable Identifier

R-HSA-870499

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

FAM, Probable ubiquitin carboxyl-terminal hydrolase FAF-X

Locations in the PathwayBrowser for interactor UniProt:O60285 NUAK1

Expand all

External Reference Information

External Reference

UniProt:Q93008 USP9X

Gene Names

USP9X, DFFRX, FAM, USP9

Chain

chain:1-2554

Reference Genes

BioGPS Gene:8239 USP9X

COSMIC (genes):USP9X USP9X

CTD Gene:8239 USP9X

dbSNP Gene:8239 USP9X

ENSEMBL:ENSG00000124486 USP9X

ENSEMBL_homo_sapiens_GENE:ENSG00000124486.15 USP9X

HGNC:12632 USP9X

KEGG Gene (Homo sapiens):8239 USP9X

Monarch:8239 USP9X

NCBI Gene:8239 USP9X

OMIM:300072 USP9X

UCSC:Q93008 USP9X

Reference Transcript

Other Identifiers

11725328_a_at

11725329_a_at

11725330_a_at

11725331_a_at

11757582_s_at

17102689

201099_PM_at

201099_at

201100_PM_s_at

201100_s_at

229573_PM_at

229573_at

32572_at

3974707

3974709

3974710

3974711

3974712

3974720

3974721

3974722

3974724

3974725

3974727

3974728

3974729

3974730

3974731

3974732

3974733

3974734

3974736

3974738

3974739

3974743

3974745

3974746

3974748

3974750

3974752

3974756

3974757

3974759

3974760

3974761

3974764

3974766

3974767

3974768

3974769

3974770

3974772

3974773

3974775

3974777

3974779

3974782

3974783

3974784

3974785

3974787

3974789

3974790

3974792

3974795

3974796

3974797

3974799

3974801

3974802

3974803

3974804

3974805

3974806

3974808

4030123

4030142

4030155

63336_at

74225_at

8166826

8239

968_i_at

969_s_at

970_r_at

A_14_P138476

A_23_P217409

A_33_P3387771

GE60205

GE867920

GO:0000122

GO:0001764

GO:0003824

GO:0004197

GO:0004843

GO:0005515

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0006281

GO:0006307

GO:0006351

GO:0006355

GO:0006508

GO:0006886

GO:0007031

GO:0007049

GO:0007059

GO:0007179

GO:0007292

GO:0008104

GO:0008233

GO:0008234

GO:0016020

GO:0016477

GO:0016562

GO:0016567

GO:0016579

GO:0016787

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030426

GO:0030509

GO:0032092

GO:0032435

GO:0035520

GO:0036211

GO:0042752

GO:0042995

GO:0043226

GO:0044782

GO:0048511

GO:0048675

GO:0048856

GO:0048870

GO:0050821

GO:0051301

GO:0055085

GO:0060271

GO:0061578

GO:0061824

GO:0070410

GO:0070536

GO:0071947

GO:0101005

GO:0140096

GO:0140313

GO:0180017

GO:1904515

GO:1990000

GO:1990380

HMNXSV003051998

Hs.128148.0.A1_3p_at

Hs.77578.0.S2_3p_at

ILMN_1656165

ILMN_2400583

PH_hs_0004475

PH_hs_0035285

TC0X000195.hg

X98296_at

g11641424_3p_a_at

Participates

as a candidate of

as an input of

as an output of

as a component of

as a member of

UCHL3,USP7,USP9X [cytosol] (Homo sapiens)

Inferred To

usp9x [cytosol] (Xenopus tropicalis)

USP9X [cytosol] (Bos taurus)

USP9X [cytosol] (Caenorhabditis elegans)

USP9X [cytosol] (Dictyostelium discoideum)

USP9X [cytosol] (Mus musculus)

USP9X [cytosol] (Sus scrofa)

USP9Y [cytosol] (Gallus gallus)

faf [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001034680.2, NP_001034679.2

OpenTargets

ENSG00000124486

ZINC - Substances

USP9X_HUMAN

ZINC target

Q93008

PRO

Q93008

PDB

7YXX, 7YXY, 5WCH, 5VBD

HPA

ENSG00000124486-USP9X

GeneCards

Q93008

Ensembl

ENSG00000124486, ENSP00000515975, ENSP00000367558, ENSP00000316357, ENST00000324545, ENST00000378308, ENST00000704650

Pharos - Targets

Q93008

Orphanet

22818

ZINC - Predictions - Purchasable

USP9X_HUMAN

HMDB Protein

HMDBP10126

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.679	10
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	8
UniProt:O60285 NUAK1	2	p-T211-NUAK1 [nucleoplasm] (R-HSA-3222011) NUAK1 [nucleoplasm] (R-HSA-3222004)	0.564	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.556	3
UniProt:P49761 CLK3			0.527	2
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.527	3
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.527	2
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.527	2
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.527	6
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) AXIN1 [cytosol] (R-HSA-195249)	0.527	2
UniProt:P08393 ICP0			0.499	3
UniProt:Q8IYB8 SUPV3L1	1	SUPV3L1 [mitochondrial matrix] (R-HSA-429828)	0.483	2

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