Reactome | Ubiquitinated SMAD4 translocates from the nucleus to the cytosol

Ubiquitinated SMAD4 translocates from the nucleus to the cytosol

Stable Identifier

R-HSA-870477

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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Ubiquitinated SMAD4 translocates from the nucleus to the cytosol

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SMAD4 monoubiquitinated by TRIM33 translocates from the nucleus to the cytosol (Dupont et al. 2009, Dupont et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
19135894	FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination Dupont, S, Mamidi, A, Cordenonsi, M, Montagner, M, Zacchigna, L, Adorno, M, Martello, G, Stinchfield, MJ, Soligo, S, Morsut, L, Inui, M, Moro, S, Modena, N, Argenton, F, Newfeld, SJ, Piccolo, S	Cell	2009
15820681	Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase Dupont, S, Zacchigna, L, Cordenonsi, M, Soligo, S, Adorno, M, Rugge, M, Piccolo, S	Cell	2005